PP1 Phosphatase complexes: Undruggable No Longer

Paola Vagnarelli; Dario R. Alessi

doi:10.1016/j.cell.2018.08.007

PP1 Phosphatase complexes: Undruggable No Longer

Paola Vagnarelli (Lead / Corresponding author)
, Dario R. Alessi (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

182 Downloads (Pure)

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

Original language	English
Pages (from-to)	1049-1051
Number of pages	3
Journal	Cell
Volume	174
Issue number	5
Early online date	23 Aug 2018
DOIs	https://doi.org/10.1016/j.cell.2018.08.007
Publication status	Published - 23 Aug 2018

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2018.08.007

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© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 142 KBLicence: CC BY-NC-ND

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abstract = "The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.",

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AU - Alessi, Dario R.

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DO - 10.1016/j.cell.2018.08.007

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JO - Cell

JF - Cell

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ER -

PP1 Phosphatase complexes: Undruggable No Longer

Abstract

ASJC Scopus subject areas

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