PPARG locus haplotype variation and exacerbations in asthma

C. N. A. Palmer, A. S. F. Doney, T. Ismail, S. P. Lee, I. Murrie, D. F. Macgregor, S. Mukhopadhyay

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates inflammation and may play a role in asthma. Using mouthwash-derived DNA and clinical interviews and measurements, we investigated the association of previously characterized single-nucleotide polymorphisms in the PPARG gene (Pro12Ala, C1431T, and C-681G) with asthma exacerbations in patients aged 3-22 years (n=569). The common homozygous haplotype combination of the Pro12 and C1431 alleles was associated with increased risk for asthma exacerbations (ProC, odds ratio (OR) 1.87, 95% confidence interval 1.25-2.79; P=0.002). The ProC genotype was associated with increased school absences (OR 1.82, 95% confidence interval 1.21-2.76; P=0.004) and hospital admissions (OR 2.32, 95% confidence interval 1.18-4.58; P=0.015) over the preceding 6 months. The population-attributable risk of this genotype was 33%. Common genetic variation at the PPARG locus may play an important role in modulating the long-term control of asthma in children and young adults.
    Original languageEnglish
    Pages (from-to)713-8
    Number of pages6
    JournalClinical Pharmacology & Therapeutics
    Volume81
    Issue number5
    DOIs
    Publication statusPublished - May 2007

    Keywords

    • Adolescent
    • Adult
    • Alleles
    • Asthma
    • Child
    • Child, Preschool
    • Confidence Intervals
    • DNA
    • Female
    • Genotype
    • Great Britain
    • Haplotypes
    • Hospitalization
    • Humans
    • Linkage Disequilibrium
    • Male
    • Odds Ratio
    • PPAR gamma
    • Risk Assessment

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