Abstract
The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates inflammation and may play a role in asthma. Using mouthwash-derived DNA and clinical interviews and measurements, we investigated the association of previously characterized single-nucleotide polymorphisms in the PPARG gene (Pro12Ala, C1431T, and C-681G) with asthma exacerbations in patients aged 3-22 years (n=569). The common homozygous haplotype combination of the Pro12 and C1431 alleles was associated with increased risk for asthma exacerbations (ProC, odds ratio (OR) 1.87, 95% confidence interval 1.25-2.79; P=0.002). The ProC genotype was associated with increased school absences (OR 1.82, 95% confidence interval 1.21-2.76; P=0.004) and hospital admissions (OR 2.32, 95% confidence interval 1.18-4.58; P=0.015) over the preceding 6 months. The population-attributable risk of this genotype was 33%. Common genetic variation at the PPARG locus may play an important role in modulating the long-term control of asthma in children and young adults.
Original language | English |
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Pages (from-to) | 713-8 |
Number of pages | 6 |
Journal | Clinical Pharmacology & Therapeutics |
Volume | 81 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2007 |
Keywords
- Adolescent
- Adult
- Alleles
- Asthma
- Child
- Child, Preschool
- Confidence Intervals
- DNA
- Female
- Genotype
- Great Britain
- Haplotypes
- Hospitalization
- Humans
- Linkage Disequilibrium
- Male
- Odds Ratio
- PPAR gamma
- Risk Assessment