PPP1R6, a novel member: Of the family of glycogen-targetting subunits of protein phosphatase 1

Christopher G. Armstrong; Gareth J. Browne; Philip Cohen; Patricia T.W. Cohen

doi:10.1016/S0014-5793(97)01385-9

PPP1R6, a novel member: Of the family of glycogen-targetting subunits of protein phosphatase 1

Christopher G. Armstrong, Gareth J. Browne, Philip Cohen, Patricia T.W. Cohen

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).

Original language	English
Pages (from-to)	210-214
Number of pages	5
Journal	FEBS Letters
Volume	418
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(97)01385-9
Publication status	Published - 24 Nov 1997

Keywords

cDNA
Glycogen metabolism
Protein phosphatase 1
Targetting subunit

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "PPP1R6, a novel member: Of the family of glycogen-targetting subunits of protein phosphatase 1",

abstract = "A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).",

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AU - Browne, Gareth J.

AU - Cohen, Philip

AU - Cohen, Patricia T.W.

PY - 1997/11/24

Y1 - 1997/11/24

N2 - A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).

AB - A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).

KW - cDNA

KW - Glycogen metabolism

KW - Protein phosphatase 1

KW - Targetting subunit

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ER -

PPP1R6, a novel member: Of the family of glycogen-targetting subunits of protein phosphatase 1

Abstract

Keywords

ASJC Scopus subject areas

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