Pre-hospital administration of unfractionated heparin in STEMI is associated with improved long term survival

C. McGinley, I. R. Mordi, P. Kelly, P. Currie, S. Hutcheon, S. Koch, T. Martin, J. Irving (Lead / Corresponding author)

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Abstract

Objective: Administration of unfractionated heparin to STEMI patients by the ambulance service is established practice in Scotland, but efficacy is unknown. We studied the effects of unfractionated heparin in STEMI patients treated by primary percutaneous coronary intervention (PPCI), on infarct artery patency and mortality.

Methods and results: Consecutive patients (n=1,000) admitted to Ninewells Hospital, Dundee, from 2010-2014 for PPCI were allocated to two groups: 437 (44%) pre-hospital heparin (PHH) administered by paramedics, and 563 (56%) in-hospital heparin (IHH). A trained medical student assessed coronary flow at presentation and collected the data. Mortality status was ascertained at 30 days and 5 years. Cox proportional hazards regression models were generated.The patient groups were similar, although PHH had shorter symptom onset-treatment time (187 min vs. 251 min, p<0.001) and less cardiogenic shock (3.9% vs. 8.0%, p=0.008). Initial coronary flow was not different between the groups. Thirty day mortality in PHH was 2.5% vs. 8.3%, p<0.001. Independent predictors of 30-day mortality were age (odds ratio 1.07, 95% CI 1.04-1.09), cardiogenic shock (5.97, 3.33-10.69), radial access (0.53, 0.28-0.98) and pre-hospital heparin (0.33, 0.17-0.66). Five year mortality in PHH was 13.0% vs. 21.6%, p<0.001. Significant predictors of long-term mortality were age (1.07, 1.06-1.09), cardiogenic shock (3.40, 2.23-5.17) and pre-hospital heparin (0.68, 0.49-0.96).

Conclusions: Pre-hospital heparin was associated with reduced short and long-term mortality after adjusting for important potential confounders.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
DOIs
Publication statusE-pub ahead of print - 22 Jun 2020

Keywords

  • Heparin
  • STEMI
  • pre-hospital treatment
  • Primary PCI

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