Pre-notification increases uptake of colorectal cancer screening in all demographic groups: a randomized controlled trial

Gillian Libby, Jane Bray, Jennifer Champion, Linda A. Brownlee, Janice Birrell, Dermot R. Gorman, Emilia M. Crighton, Callum G. Fraser, Robert J. C. Steele

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Objectives To assess whether pre-notification is effective in increasing uptake of colorectal cancer screening for all demographic groups.

    Setting Scottish national colorectal cancer screening programme.

    Methods Males and females aged 50-74 years received a faecal occult blood test by post to complete at home. They were randomized to receive in addition: the pre-notification letter, the pre-notification letter + information booklet, or the usual invitation. Overall, 59,953 subjects were included in the trial between 13/04/09 and 29/05/09 and followed to 27/11/09. Pre-notification letters were posted two weeks ahead of the screening test kit. Uptake was defined as the return of a screening test and chi-squared tests compared uptake between the trial arms. Logistic regression assessed the impact of the letter and letter + booklet on uptake independently of gender, age, deprivation and screening round.

    Results Uptake was higher with both the letter (59.0%) and the letter + booklet (58.5%) compared with the usual invitation (53.9%, p < 0.0001). This increased uptake was seen for males, females, all age groups and all deprivation categories including least deprived females (letter 69.9%, usual invitation 66.6%) and most deprived males (42.6% vs. 36.1%), the groups with the highest and lowest levels of uptake respectively in the pilot screening rounds conducted prior to the roll out of the programme. Uptake with the pre-notification letter compared with the usual invitation was higher both unadjusted and adjusted for demographic factors (odds ratio 1.24, 95% Cl 1.193-1.294).

    Conclusions Pre-notification is an effective method of increasing uptake in colorectal cancer screening for both genders and all age and deprivation groups.

    Original languageEnglish
    Pages (from-to)24-29
    Number of pages6
    JournalJournal of Medical Screening
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Pilot

    Cite this

    Libby, Gillian ; Bray, Jane ; Champion, Jennifer ; Brownlee, Linda A. ; Birrell, Janice ; Gorman, Dermot R. ; Crighton, Emilia M. ; Fraser, Callum G. ; Steele, Robert J. C. / Pre-notification increases uptake of colorectal cancer screening in all demographic groups : a randomized controlled trial. In: Journal of Medical Screening. 2011 ; Vol. 18, No. 1. pp. 24-29.
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    title = "Pre-notification increases uptake of colorectal cancer screening in all demographic groups: a randomized controlled trial",
    abstract = "Objectives To assess whether pre-notification is effective in increasing uptake of colorectal cancer screening for all demographic groups.Setting Scottish national colorectal cancer screening programme.Methods Males and females aged 50-74 years received a faecal occult blood test by post to complete at home. They were randomized to receive in addition: the pre-notification letter, the pre-notification letter + information booklet, or the usual invitation. Overall, 59,953 subjects were included in the trial between 13/04/09 and 29/05/09 and followed to 27/11/09. Pre-notification letters were posted two weeks ahead of the screening test kit. Uptake was defined as the return of a screening test and chi-squared tests compared uptake between the trial arms. Logistic regression assessed the impact of the letter and letter + booklet on uptake independently of gender, age, deprivation and screening round.Results Uptake was higher with both the letter (59.0{\%}) and the letter + booklet (58.5{\%}) compared with the usual invitation (53.9{\%}, p < 0.0001). This increased uptake was seen for males, females, all age groups and all deprivation categories including least deprived females (letter 69.9{\%}, usual invitation 66.6{\%}) and most deprived males (42.6{\%} vs. 36.1{\%}), the groups with the highest and lowest levels of uptake respectively in the pilot screening rounds conducted prior to the roll out of the programme. Uptake with the pre-notification letter compared with the usual invitation was higher both unadjusted and adjusted for demographic factors (odds ratio 1.24, 95{\%} Cl 1.193-1.294).Conclusions Pre-notification is an effective method of increasing uptake in colorectal cancer screening for both genders and all age and deprivation groups.",
    keywords = "Pilot",
    author = "Gillian Libby and Jane Bray and Jennifer Champion and Brownlee, {Linda A.} and Janice Birrell and Gorman, {Dermot R.} and Crighton, {Emilia M.} and Fraser, {Callum G.} and Steele, {Robert J. C.}",
    year = "2011",
    doi = "10.1258/jms.2011.011002",
    language = "English",
    volume = "18",
    pages = "24--29",
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    Pre-notification increases uptake of colorectal cancer screening in all demographic groups : a randomized controlled trial. / Libby, Gillian; Bray, Jane; Champion, Jennifer; Brownlee, Linda A.; Birrell, Janice; Gorman, Dermot R.; Crighton, Emilia M.; Fraser, Callum G.; Steele, Robert J. C.

    In: Journal of Medical Screening, Vol. 18, No. 1, 2011, p. 24-29.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Pre-notification increases uptake of colorectal cancer screening in all demographic groups

    T2 - a randomized controlled trial

    AU - Libby, Gillian

    AU - Bray, Jane

    AU - Champion, Jennifer

    AU - Brownlee, Linda A.

    AU - Birrell, Janice

    AU - Gorman, Dermot R.

    AU - Crighton, Emilia M.

    AU - Fraser, Callum G.

    AU - Steele, Robert J. C.

    PY - 2011

    Y1 - 2011

    N2 - Objectives To assess whether pre-notification is effective in increasing uptake of colorectal cancer screening for all demographic groups.Setting Scottish national colorectal cancer screening programme.Methods Males and females aged 50-74 years received a faecal occult blood test by post to complete at home. They were randomized to receive in addition: the pre-notification letter, the pre-notification letter + information booklet, or the usual invitation. Overall, 59,953 subjects were included in the trial between 13/04/09 and 29/05/09 and followed to 27/11/09. Pre-notification letters were posted two weeks ahead of the screening test kit. Uptake was defined as the return of a screening test and chi-squared tests compared uptake between the trial arms. Logistic regression assessed the impact of the letter and letter + booklet on uptake independently of gender, age, deprivation and screening round.Results Uptake was higher with both the letter (59.0%) and the letter + booklet (58.5%) compared with the usual invitation (53.9%, p < 0.0001). This increased uptake was seen for males, females, all age groups and all deprivation categories including least deprived females (letter 69.9%, usual invitation 66.6%) and most deprived males (42.6% vs. 36.1%), the groups with the highest and lowest levels of uptake respectively in the pilot screening rounds conducted prior to the roll out of the programme. Uptake with the pre-notification letter compared with the usual invitation was higher both unadjusted and adjusted for demographic factors (odds ratio 1.24, 95% Cl 1.193-1.294).Conclusions Pre-notification is an effective method of increasing uptake in colorectal cancer screening for both genders and all age and deprivation groups.

    AB - Objectives To assess whether pre-notification is effective in increasing uptake of colorectal cancer screening for all demographic groups.Setting Scottish national colorectal cancer screening programme.Methods Males and females aged 50-74 years received a faecal occult blood test by post to complete at home. They were randomized to receive in addition: the pre-notification letter, the pre-notification letter + information booklet, or the usual invitation. Overall, 59,953 subjects were included in the trial between 13/04/09 and 29/05/09 and followed to 27/11/09. Pre-notification letters were posted two weeks ahead of the screening test kit. Uptake was defined as the return of a screening test and chi-squared tests compared uptake between the trial arms. Logistic regression assessed the impact of the letter and letter + booklet on uptake independently of gender, age, deprivation and screening round.Results Uptake was higher with both the letter (59.0%) and the letter + booklet (58.5%) compared with the usual invitation (53.9%, p < 0.0001). This increased uptake was seen for males, females, all age groups and all deprivation categories including least deprived females (letter 69.9%, usual invitation 66.6%) and most deprived males (42.6% vs. 36.1%), the groups with the highest and lowest levels of uptake respectively in the pilot screening rounds conducted prior to the roll out of the programme. Uptake with the pre-notification letter compared with the usual invitation was higher both unadjusted and adjusted for demographic factors (odds ratio 1.24, 95% Cl 1.193-1.294).Conclusions Pre-notification is an effective method of increasing uptake in colorectal cancer screening for both genders and all age and deprivation groups.

    KW - Pilot

    U2 - 10.1258/jms.2011.011002

    DO - 10.1258/jms.2011.011002

    M3 - Article

    C2 - 21536813

    VL - 18

    SP - 24

    EP - 29

    JO - Journal of Medical Screening

    JF - Journal of Medical Screening

    SN - 0969-1413

    IS - 1

    ER -