Abstract
Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.
Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.
Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions
| Original language | English |
|---|---|
| Pages (from-to) | 383-389 |
| Number of pages | 7 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 171 |
| Issue number | 2 |
| Early online date | 1 Jun 2018 |
| DOIs | |
| Publication status | Published - 1 Jun 2018 |
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Keywords
- Breast cancer
- Prognosis
- Shear wave elastography
- Ultrasound
- Neoadjuvant chemotherapy
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Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. / Evans, Andy (Lead / Corresponding author); Sim, Yee Ting; Pourreyron, Celine; Thompson, Alastair; Jordan, Lee; Fleming, Dawn; Purdie, Colin; Macaskill, Jane; Vinnicombe, Sarah; Pharoah, Paul.
In: Breast Cancer Research and Treatment, Vol. 171, No. 2, 01.06.2018, p. 383-389.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival
AU - Evans, Andy
AU - Sim, Yee Ting
AU - Pourreyron, Celine
AU - Thompson, Alastair
AU - Jordan, Lee
AU - Fleming, Dawn
AU - Purdie, Colin
AU - Macaskill, Jane
AU - Vinnicombe, Sarah
AU - Pharoah, Paul
N1 - Funding: none.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions
AB - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions
KW - Breast cancer
KW - Prognosis
KW - Shear wave elastography
KW - Ultrasound
KW - Neoadjuvant chemotherapy
U2 - 10.1007/s10549-018-4836-5
DO - 10.1007/s10549-018-4836-5
M3 - Article
C2 - 29858751
VL - 171
SP - 383
EP - 389
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -