Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Andy  Evans; Yee Ting Sim; Celine Pourreyron; Alastair Thompson; Lee Jordan; Dawn Fleming; Colin Purdie; Jane Macaskill; Sarah Vinnicombe; Paul Pharoah

doi:10.1007/s10549-018-4836-5

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Andy Evans (Lead / Corresponding author), Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah

Research output: Contribution to journal › Article

6 Citations (Scopus)

135 Downloads (Pure)

Abstract

Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).

Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.

Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.
Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions

Original language	English
Pages (from-to)	383-389
Number of pages	7
Journal	Breast Cancer Research and Treatment
Volume	171
Issue number	2
Early online date	1 Jun 2018
DOIs	https://doi.org/10.1007/s10549-018-4836-5
Publication status	Published - 1 Jun 2018

Keywords

Breast cancer
Prognosis
Shear wave elastography
Ultrasound
Neoadjuvant chemotherapy

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Evans, Andrew

Imaging Science and Technology - Clinical Professor (Teaching and Research)

Person: Academic

Cite this

Evans, A., Sim, Y. T., Pourreyron, C., Thompson, A., Jordan, L., Fleming, D., Purdie, C., Macaskill, J., Vinnicombe, S., & Pharoah, P. (2018). Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. Breast Cancer Research and Treatment, 171(2), 383-389. https://doi.org/10.1007/s10549-018-4836-5

Evans, Andy ; Sim, Yee Ting ; Pourreyron, Celine ; Thompson, Alastair ; Jordan, Lee ; Fleming, Dawn ; Purdie, Colin ; Macaskill, Jane ; Vinnicombe, Sarah ; Pharoah, Paul. / Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. In: Breast Cancer Research and Treatment. 2018 ; Vol. 171, No. 2. pp. 383-389.

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title = "Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival",

abstract = "Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions",

keywords = "Breast cancer, Prognosis, Shear wave elastography, Ultrasound, Neoadjuvant chemotherapy",

author = "Andy Evans and Sim, {Yee Ting} and Celine Pourreyron and Alastair Thompson and Lee Jordan and Dawn Fleming and Colin Purdie and Jane Macaskill and Sarah Vinnicombe and Paul Pharoah",

note = "Funding: none.",

year = "2018",

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doi = "10.1007/s10549-018-4836-5",

language = "English",

volume = "171",

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Evans, A, Sim, YT, Pourreyron, C, Thompson, A, Jordan, L, Fleming, D, Purdie, C, Macaskill, J, Vinnicombe, S & Pharoah, P 2018, 'Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival', Breast Cancer Research and Treatment, vol. 171, no. 2, pp. 383-389. https://doi.org/10.1007/s10549-018-4836-5

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. / Evans, Andy (Lead / Corresponding author); Sim, Yee Ting; Pourreyron, Celine; Thompson, Alastair; Jordan, Lee; Fleming, Dawn; Purdie, Colin; Macaskill, Jane; Vinnicombe, Sarah; Pharoah, Paul.

In: Breast Cancer Research and Treatment, Vol. 171, No. 2, 01.06.2018, p. 383-389.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

AU - Evans, Andy

AU - Sim, Yee Ting

AU - Pourreyron, Celine

AU - Thompson, Alastair

AU - Jordan, Lee

AU - Fleming, Dawn

AU - Purdie, Colin

AU - Macaskill, Jane

AU - Vinnicombe, Sarah

AU - Pharoah, Paul

N1 - Funding: none.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions

AB - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions

KW - Breast cancer

KW - Prognosis

KW - Shear wave elastography

KW - Ultrasound

KW - Neoadjuvant chemotherapy

U2 - 10.1007/s10549-018-4836-5

DO - 10.1007/s10549-018-4836-5

M3 - Article

C2 - 29858751

VL - 171

SP - 383

EP - 389

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -