Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

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• Finished

  Wellcome Centre for Anti-Infectives Research

  Baragana, B. (Investigator), Cook, S. (Investigator), De Rycker, M. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator), Lee, M. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & Wyllie, S. (Investigator)

  1/04/17 → 1/04/25

  Project: Research

  • Drug Discovery 100%
  • Trypanosoma Cruzi (T. cruzi) 88%
  • Chagas Disease 71%
  • Trypanosoma Cruzi 69%
  • Visceral Leishmaniasis 57%

• Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

  Fairlamb, A. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator) & Wyatt, P. (Investigator)

  1/01/15 → 31/12/20

  Project: Research

  • Visceral Leishmaniasis 100%
  • Drug Discovery 96%
  • Chagas Disease 85%
  • Leishmania Donovani 84%
  • Trypanosoma Cruzi (T. cruzi) 76%

• Protein Glycosylation in Trypanosomes: Defining and Exploiting a Biological System (Senior Investigator Award)

  Ferguson, M. (Investigator)

  1/10/13 → 30/06/23

  Project: Research

  • Trypanosoma Brucei 100%
  • GPI-anchored Protein (GPI-AP) 40%
  • Bloodstream Forms 37%
  • T. Brucei 35%
  • Trypanosoma 33%

• High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)

  Horn, D. (Investigator)

  1/09/13 → 29/02/20

  Project: Research

  • Trypanosoma 100%
  • Trypanosoma Brucei 71%
  • African Trypanosomes 68%
  • Trypanosome 58%
  • Spike Glycoprotein 41%

• A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Proteolysis 73%
  • Visceral Leishmaniasis 67%
  • Trypanosoma Brucei 61%
  • Ubiquitin-Conjugating Enzyme 60%

• Discovery and Development of Drug Candidates for Neglected Diseases (joint with industrial partner)

  Brenk, R. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Hopkins, A. (Investigator), Horn, D. (Investigator), Read, K. (Investigator), Wyatt, P. (Investigator) & van Aalten, D. (Investigator)

  1/02/11 → 1/07/17

  Project: Research

  • Visceral Leishmaniasis 100%
  • Trypanosoma Brucei 80%
  • Trypanosoma Cruzi (T. cruzi) 76%
  • N-myristoyltransferase 65%
  • Diseases 64%