Predicting burst pressure of radiofrequency-induced colorectal anastomosis by bio-impedance measurement

Lingxi Zhao, Yu Zhou, Chengli Song (Lead / Corresponding author), Zhigang Wang, Alfred Cuschieri

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    Abstract

    The present study investigates the relationship between bio-impedance and burst pressure of colorectal anastomosis created by radiofrequency (RF)-induced tissue fusion. Colorectal anastomosis were created with ex-vivo porcine colorectal segments, during which 5 levels of compression pressure were applied by a custom-made bipolar prototype, with 5 replicate experiments at each compression pressure. Instant anastomotic tensile strength was assessed by burst pressure. Bio-impedance of fused tissue was measured by Impedance Analyzer across frequency that 100Hz to 3MHz. Statistical analysis shows only a weak correlation between bioimpedance modulus and burst pressures at frequency of 445 kHz (ρs= -0.426, P=0.099>0.05). In contrast, results demonstrated a highly significant negative correlation between reactance modulus and burst pressures (ρs= -0.812, P=0.000<0.05). The decrease in mean reactance modulus with increasing burst pressures was highly significant (p=0.019<0.05). The observed strong negative correlation between reactance modulus and burst pressures at frequency of 445 kHz indicates that reactance is likely to be a good index for tensile strength of RF-induced colorectal anastomosis, and should be considered for inclusion in a feedback loops in devices design.
    Original languageEnglish
    Pages (from-to)489-500
    Number of pages12
    JournalPhysiological Measurement
    Volume38
    Issue number3
    DOIs
    Publication statusPublished - 8 Feb 2017

    Keywords

    • Radiofrequency
    • colorectal anastomosis
    • burst pressure
    • bio-impedance
    • reactance

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