Predicting mortality using two renal function estimation methods in hospitalised stroke patients

Louise F. Porter, Miles D. Witham, Callum G. Fraser, Ronald S. MacWalter

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    2 Citations (Scopus)


    The prognostic abilities of the MDRD and Cockcroft-Gault methods for estimating renal function were compared in a cohort study of 1287 patients with acute stroke admitted to a Scottish tertiary care teaching hospital. Using Cox regression analysis corrected for other prognostic variables, both the MDRD and Cockcroft-Gault equations predicted mortality independently of other prognostic factors. A 1 ml/min reduction in GFR as calculated by MDRD was associated with a 1.0% 95% CI: 0.3-1.6) increase in risk of death. A 1 ml/min reduction in creatinine clearance from the Cockcroft-Gault equation was associated with a 1.7% 95% CI: 0.9-2.6) increase in risk of death. The Cockcroft-Gault equation weakly predicted length of stay r = 0.066, p = 0.02, Spearman's rank test). In conclusion, both methods independently predict early and late mortality in stroke patients, but the Cockcroft-Gault estimate has greater predictive power in this population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)307-309
    Number of pages3
    JournalInternational Journal of Cardiology
    Issue number3
    Publication statusPublished - 18 Mar 2010


    • Creatinine clearance
    • MDRD equation
    • Prognosis
    • Renal function
    • Stroke


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