Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins

Michael J. E. Sternberg (Lead / Corresponding author), Geoffrey J. Barton, Marketa J. Zvelebil, John Cookson, Anthony R. M. Coates

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition to the env gene envelope glycoproteins being actively studied. The predictions of B- and T-epitopes are refined by consideration of secondary structure prediction and inter-isolate sequence variability to suggest peptides from env, gag and pol that would be the best vaccine candidates.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalFEBS Letters
Volume218
Issue number2
DOIs
Publication statusPublished - 29 Jun 1987

Keywords

  • Amino acid sequence
  • Epitopes
  • HIV
  • Protein conformation
  • Retroviridae proteins
  • Viral vaccines

Fingerprint Dive into the research topics of 'Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins'. Together they form a unique fingerprint.

  • Cite this