Abstract
Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition to the env gene envelope glycoproteins being actively studied. The predictions of B- and T-epitopes are refined by consideration of secondary structure prediction and inter-isolate sequence variability to suggest peptides from env, gag and pol that would be the best vaccine candidates.
Original language | English |
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Pages (from-to) | 231-237 |
Number of pages | 7 |
Journal | FEBS Letters |
Volume | 218 |
Issue number | 2 |
DOIs | |
Publication status | Published - 29 Jun 1987 |
Keywords
- Amino acid sequence
- Epitopes
- HIV
- Protein conformation
- Retroviridae proteins
- Viral vaccines