Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar Jovanović (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

Original languageEnglish
Pages (from-to)96-98
Number of pages3
JournalPregnancy Hypertension
Volume18
Early online date1 Oct 2019
DOIs
Publication statusPublished - Oct 2019

Fingerprint

Pregnancy Induced Hypertension
Myometrium
KATP Channels
Down-Regulation
Parturition
Membrane Potentials
Real-Time Polymerase Chain Reaction
Adenosine Triphosphate
Pregnancy
Messenger RNA

Keywords

  • ATP-sensitive K channels
  • PIH
  • Uterus

Cite this

Du, Qingyou ; Jovanović, Sofija ; Tulić, Lidija ; Tulić, Ivan ; Jovanović, Aleksandar. / Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. In: Pregnancy Hypertension. 2019 ; Vol. 18. pp. 96-98.
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Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. / Du, Qingyou; Jovanović, Sofija; Tulić, Lidija; Tulić, Ivan; Jovanović, Aleksandar (Lead / Corresponding author).

In: Pregnancy Hypertension, Vol. 18, 10.2019, p. 96-98.

Research output: Contribution to journalArticle

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