Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar Jovanović (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

Original languageEnglish
Pages (from-to)96-98
Number of pages3
JournalPregnancy Hypertension
Volume18
Early online date1 Oct 2019
DOIs
Publication statusPublished - Oct 2019

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Keywords

  • ATP-sensitive K channels
  • PIH
  • Uterus

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