Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du; Sofija Jovanović; Lidija Tulić; Ivan Tulić; Aleksandar Jovanović

doi:10.1016/j.preghy.2019.09.008

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar Jovanović (Lead / Corresponding author)

Research output: Contribution to journal › Article

Abstract

It is generally accepted that activity of K⁺ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K⁺ (K_ATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of K_ATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial K_ATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

Original language	English
Pages (from-to)	96-98
Number of pages	3
Journal	Pregnancy Hypertension
Volume	18
Early online date	1 Oct 2019
DOIs	https://doi.org/10.1016/j.preghy.2019.09.008
Publication status	Published - Oct 2019

Fingerprint

Pregnancy Induced Hypertension

Myometrium

KATP Channels

Down-Regulation

Parturition

Membrane Potentials

Real-Time Polymerase Chain Reaction

Adenosine Triphosphate

Pregnancy

Messenger RNA

Keywords

ATP-sensitive K channels
PIH
Uterus

Cite this

Du, Q., Jovanović, S., Tulić, L., Tulić, I., & Jovanović, A. (2019). Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. Pregnancy Hypertension, 18, 96-98. https://doi.org/10.1016/j.preghy.2019.09.008

Du, Qingyou ; Jovanović, Sofija ; Tulić, Lidija ; Tulić, Ivan ; Jovanović, Aleksandar. / Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. In: Pregnancy Hypertension. 2019 ; Vol. 18. pp. 96-98.

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abstract = "It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.",

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Du, Q, Jovanović, S, Tulić, L, Tulić, I & Jovanović, A 2019, 'Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium', Pregnancy Hypertension, vol. 18, pp. 96-98. https://doi.org/10.1016/j.preghy.2019.09.008

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. / Du, Qingyou; Jovanović, Sofija; Tulić, Lidija; Tulić, Ivan; Jovanović, Aleksandar (Lead / Corresponding author).

In: Pregnancy Hypertension, Vol. 18, 10.2019, p. 96-98.

Research output: Contribution to journal › Article

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AU - Jovanović, Aleksandar

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AB - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

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