TY - JOUR
T1 - Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium
AU - Du, Qingyou
AU - Jovanović, Sofija
AU - Tulić, Lidija
AU - Tulić, Ivan
AU - Jovanović, Aleksandar
PY - 2019/10
Y1 - 2019/10
N2 - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.
AB - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.
KW - ATP-sensitive K channels
KW - PIH
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=85072729690&partnerID=8YFLogxK
U2 - 10.1016/j.preghy.2019.09.008
DO - 10.1016/j.preghy.2019.09.008
M3 - Article
C2 - 31585348
AN - SCOPUS:85072729690
VL - 18
SP - 96
EP - 98
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
SN - 2210-7789
ER -