Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du; Sofija Jovanović; Lidija Tulić; Ivan Tulić; Aleksandar Jovanović

doi:10.1016/j.preghy.2019.09.008

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar Jovanović (Lead / Corresponding author)

Research output: Contribution to journal › Article

Abstract

It is generally accepted that activity of K⁺ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K⁺ (K_ATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of K_ATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial K_ATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

Original language	English
Pages (from-to)	96-98
Number of pages	3
Journal	Pregnancy Hypertension
Volume	18
Early online date	1 Oct 2019
DOIs	https://doi.org/10.1016/j.preghy.2019.09.008
Publication status	Published - Oct 2019

Fingerprint

Keywords

ATP-sensitive K channels
PIH
Uterus

Cite this

Du, Q., Jovanović, S., Tulić, L., Tulić, I., & Jovanović, A. (2019). Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium. Pregnancy Hypertension, 18, 96-98. https://doi.org/10.1016/j.preghy.2019.09.008

@article{423cca0a54ad44ec9c2f523fb21b9f7f,

title = "Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium",

abstract = "It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.",

keywords = "ATP-sensitive K channels, PIH, Uterus",

author = "Qingyou Du and Sofija Jovanovi{\'c} and Lidija Tuli{\'c} and Ivan Tuli{\'c} and Aleksandar Jovanovi{\'c}",

year = "2019",

month = oct,

doi = "10.1016/j.preghy.2019.09.008",

language = "English",

volume = "18",

pages = "96--98",

journal = "Pregnancy Hypertension",

issn = "2210-7789",

publisher = "Elsevier",

}

TY - JOUR

T1 - Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

AU - Du, Qingyou

AU - Jovanović, Sofija

AU - Tulić, Lidija

AU - Tulić, Ivan

AU - Jovanović, Aleksandar

PY - 2019/10

Y1 - 2019/10

N2 - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

AB - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

KW - ATP-sensitive K channels

KW - PIH

KW - Uterus

UR - http://www.scopus.com/inward/record.url?scp=85072729690&partnerID=8YFLogxK

U2 - 10.1016/j.preghy.2019.09.008

DO - 10.1016/j.preghy.2019.09.008

M3 - Article

C2 - 31585348

AN - SCOPUS:85072729690

VL - 18

SP - 96

EP - 98

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

SN - 2210-7789

ER -

Access to Document

10.1016/j.preghy.2019.09.008Licence: Elsevier User Licence

Link to publication in Scopus