Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du; Sofija Jovanović; Lidija Tulić; Ivan Tulić; Aleksandar Jovanović

doi:10.1016/j.preghy.2019.09.008

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Qingyou Du, Sofija Jovanović, Lidija Tulić, Ivan Tulić, Aleksandar Jovanović (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Abstract

It is generally accepted that activity of K⁺ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K⁺ (K_ATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of K_ATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial K_ATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

Original language	English
Pages (from-to)	96-98
Number of pages	3
Journal	Pregnancy Hypertension
Volume	18
Early online date	1 Oct 2019
DOIs	https://doi.org/10.1016/j.preghy.2019.09.008
Publication status	Published - Oct 2019

Keywords

ATP-sensitive K channels
PIH
Uterus

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title = "Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium",

abstract = "It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.",

keywords = "ATP-sensitive K channels, PIH, Uterus",

author = "Qingyou Du and Sofija Jovanovi{\'c} and Lidija Tuli{\'c} and Ivan Tuli{\'c} and Aleksandar Jovanovi{\'c}",

year = "2019",

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doi = "10.1016/j.preghy.2019.09.008",

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AU - Tulić, Lidija

AU - Tulić, Ivan

AU - Jovanović, Aleksandar

PY - 2019/10

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N2 - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

AB - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

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