Abstract
It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.
Original language | English |
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Pages (from-to) | 96-98 |
Number of pages | 3 |
Journal | Pregnancy Hypertension |
Volume | 18 |
Early online date | 1 Oct 2019 |
DOIs | |
Publication status | Published - Oct 2019 |
Keywords
- ATP-sensitive K channels
- PIH
- Uterus
ASJC Scopus subject areas
- Internal Medicine
- Obstetrics and Gynaecology