Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

TY - JOUR

T1 - Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

AU - Du, Qingyou

AU - Jovanović, Sofija

AU - Tulić, Lidija

AU - Tulić, Ivan

AU - Jovanović, Aleksandar

PY - 2019/10

Y1 - 2019/10

N2 - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

AB - It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH.

KW - ATP-sensitive K channels

KW - PIH

KW - Uterus

UR - https://www.scopus.com/pages/publications/85072729690

U2 - 10.1016/j.preghy.2019.09.008

DO - 10.1016/j.preghy.2019.09.008

M3 - Article

C2 - 31585348

AN - SCOPUS:85072729690

SN - 2210-7789

VL - 18

SP - 96

EP - 98

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

ER -