Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial

David Sebag-Montefiore (Lead / Corresponding author), Richard J Stephens, Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Phil Quirke, Jean Couture, Catherine de Metz, Arthur Sun Myint, Eric Bessell, Gareth Griffiths, Lindsay C Thompson, Mahesh Parmar

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    Abstract

    Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer. However, improvements in surgery and histopathological assessment mean that the role of radiotherapy needs to be reassessed. We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy.
    Original languageEnglish
    Pages (from-to)811-20
    Number of pages10
    JournalLancet
    Volume373
    Issue number9666
    DOIs
    Publication statusPublished - 2009

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  • Cite this

    Sebag-Montefiore, D., Stephens, R. J., Steele, R., Monson, J., Grieve, R., Khanna, S., Quirke, P., Couture, J., de Metz, C., Myint, A. S., Bessell, E., Griffiths, G., Thompson, L. C., & Parmar, M. (2009). Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet, 373(9666), 811-20. https://doi.org/10.1016/S0140-6736(09)60484-0