Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial

David Sebag-Montefiore; Richard J Stephens; Robert Steele; John Monson; Robert Grieve; Subhash Khanna; Phil Quirke; Jean Couture; Catherine de Metz; Arthur Sun Myint; Eric Bessell; Gareth Griffiths; Lindsay C Thompson; Mahesh Parmar

doi:10.1016/S0140-6736(09)60484-0

Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial

David Sebag-Montefiore (Lead / Corresponding author), Richard J Stephens, Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Phil Quirke, Jean Couture, Catherine de Metz, Arthur Sun Myint, Eric Bessell, Gareth Griffiths, Lindsay C Thompson, Mahesh Parmar

Research output: Contribution to journal › Article › peer-review

1302 Citations (Scopus)

Abstract

Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer. However, improvements in surgery and histopathological assessment mean that the role of radiotherapy needs to be reassessed. We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy.

Original language	English
Pages (from-to)	811-20
Number of pages	10
Journal	Lancet
Volume	373
Issue number	9666
DOIs	https://doi.org/10.1016/S0140-6736(09)60484-0
Publication status	Published - 2009

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10.1016/S0140-6736(09)60484-0

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Sebag-Montefiore, D., Stephens, R. J., Steele, R., Monson, J., Grieve, R., Khanna, S., Quirke, P., Couture, J., de Metz, C., Myint, A. S., Bessell, E., Griffiths, G., Thompson, L. C., & Parmar, M. (2009). Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet, 373(9666), 811-20. https://doi.org/10.1016/S0140-6736(09)60484-0

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title = "Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial",

abstract = "Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer. However, improvements in surgery and histopathological assessment mean that the role of radiotherapy needs to be reassessed. We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy.",

author = "David Sebag-Montefiore and Stephens, {Richard J} and Robert Steele and John Monson and Robert Grieve and Subhash Khanna and Phil Quirke and Jean Couture and {de Metz}, Catherine and Myint, {Arthur Sun} and Eric Bessell and Gareth Griffiths and Thompson, {Lindsay C} and Mahesh Parmar",

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doi = "10.1016/S0140-6736(09)60484-0",

language = "English",

volume = "373",

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Sebag-Montefiore, D, Stephens, RJ, Steele, R, Monson, J, Grieve, R, Khanna, S, Quirke, P, Couture, J, de Metz, C, Myint, AS, Bessell, E, Griffiths, G, Thompson, LC & Parmar, M 2009, 'Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial', Lancet, vol. 373, no. 9666, pp. 811-20. https://doi.org/10.1016/S0140-6736(09)60484-0

Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. / Sebag-Montefiore, David (Lead / Corresponding author); Stephens, Richard J; Steele, Robert et al.
In: Lancet, Vol. 373, No. 9666, 2009, p. 811-20.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016)

T2 - a multicentre, randomised trial

AU - Sebag-Montefiore, David

AU - Stephens, Richard J

AU - Steele, Robert

AU - Monson, John

AU - Grieve, Robert

AU - Khanna, Subhash

AU - Quirke, Phil

AU - Couture, Jean

AU - de Metz, Catherine

AU - Myint, Arthur Sun

AU - Bessell, Eric

AU - Griffiths, Gareth

AU - Thompson, Lindsay C

AU - Parmar, Mahesh

PY - 2009

Y1 - 2009

N2 - Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer. However, improvements in surgery and histopathological assessment mean that the role of radiotherapy needs to be reassessed. We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy.

AB - Preoperative or postoperative radiotherapy reduces the risk of local recurrence in patients with operable rectal cancer. However, improvements in surgery and histopathological assessment mean that the role of radiotherapy needs to be reassessed. We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy.

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U2 - 10.1016/S0140-6736(09)60484-0

DO - 10.1016/S0140-6736(09)60484-0

M3 - Article

C2 - 19269519

SN - 0140-6736

VL - 373

SP - 811

EP - 820

JO - Lancet

JF - Lancet

IS - 9666

ER -

Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial

Abstract

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