Preparation and characterisation of novel polycaprolactone-chitosan blends

Richard A. Rothwell, Mark S. Pridham, Gareth A. Thomson

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    This research paper reports on the production of a biocompatible and biodegradable material to be used in a polymer stent used for counteracting the occurrence of anastomotic leakage following gastrointestinal surgery. Chitosan was blended with polycaprolactone in a solvent mixture of acetic acid and water. Membranes were formed with a range of 50/50%, 60/40%, 65/35%, 70/30% and 80/20% polycaprolactone/chitosan. The tensile properties of the blends were examined over a time period to access material degradation. In addition the biocompatibilities of the polycaprolactone/chitosan blends were tested for cytotoxic effect using primary tendon fibroblastic cells. This research concluded that the polycaprolactone/chitosan was non-toxic to the fibroblasts cells in-vitro. Analysis of the mechanical properties of the blends showed a range of mechanical strengths and polymer life spans. Overall, blends of 65/35%, 70/30% and 80/20% polycaprolactone/chitosan emerged as possible candidates for the production of a gastrointestinal stent.
    Original languageEnglish
    Pages (from-to)264-274
    Number of pages11
    JournalInternational Journal of Medical Engineering and Informatics
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - Oct 2011

    Fingerprint

    Polycaprolactone
    Chitosan
    Stents
    Polymers
    Anastomotic Leak
    Tendons
    Biocompatible Materials
    Fibroblasts
    Biocompatibility
    Tensile properties
    Acetic acid
    Acetic Acid
    Surgery
    Strength of materials
    Cells
    polycaprolactone
    Membranes
    Degradation
    Mechanical properties
    Water

    Keywords

    • Anastomotic leakage
    • Bioabsorbable
    • Chitosan
    • Polycaprolactone
    • Stent

    Cite this

    Rothwell, Richard A. ; Pridham, Mark S. ; Thomson, Gareth A. / Preparation and characterisation of novel polycaprolactone-chitosan blends. In: International Journal of Medical Engineering and Informatics. 2011 ; Vol. 3, No. 3. pp. 264-274.
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    abstract = "This research paper reports on the production of a biocompatible and biodegradable material to be used in a polymer stent used for counteracting the occurrence of anastomotic leakage following gastrointestinal surgery. Chitosan was blended with polycaprolactone in a solvent mixture of acetic acid and water. Membranes were formed with a range of 50/50{\%}, 60/40{\%}, 65/35{\%}, 70/30{\%} and 80/20{\%} polycaprolactone/chitosan. The tensile properties of the blends were examined over a time period to access material degradation. In addition the biocompatibilities of the polycaprolactone/chitosan blends were tested for cytotoxic effect using primary tendon fibroblastic cells. This research concluded that the polycaprolactone/chitosan was non-toxic to the fibroblasts cells in-vitro. Analysis of the mechanical properties of the blends showed a range of mechanical strengths and polymer life spans. Overall, blends of 65/35{\%}, 70/30{\%} and 80/20{\%} polycaprolactone/chitosan emerged as possible candidates for the production of a gastrointestinal stent.",
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    Preparation and characterisation of novel polycaprolactone-chitosan blends. / Rothwell, Richard A.; Pridham, Mark S.; Thomson, Gareth A.

    In: International Journal of Medical Engineering and Informatics, Vol. 3, No. 3, 10.2011, p. 264-274.

    Research output: Contribution to journalArticle

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