Preparation, biological & cheminformatics-based assessment of N²,N⁴-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials

Keyphrases

• Plasmodium Falciparum 100%
• Cheminformatics 100%
• Diamine 100%
• Diphenylpyrimidine 100%
• Cytotoxicity 66%
• Low Permeability 33%
• Most Probable 33%
• Molecular Docking 33%
• Proteome 33%
• Binding Mode 33%
• Human Target 33%
• IC50 33%
• Homology Modeling 33%
• Metabolic Stability 33%
• HepG2 33%
• Inhibition Rate 33%
• ChEMBL Database 33%
• HepG2 Cell Line 33%
• Lipophilicity 33%
• Similarity Search 33%
• Structural Modification 33%
• Chemometrics 33%
• Sequence-based 33%
• Antitarget 33%
• Ligand-based 33%
• In Vivo Clearance 33%
• Plasmodium Falciparum 3D7 33%
• Biological Testing 33%
• LogD7.4 33%
• 3D7 Strain 33%
• Human Analogues 33%
• In Vitro Biological 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Plasmodium falciparum 100%
• Phosphotransferase 100%
• Antimalarial Agent 100%
• Cytotoxicity 66%
• Structure Activity Relationship 33%
• IC50 33%
• Lipophilicity 33%
• Plasmodium Falciparum 3D7 33%
• Antitarget 33%