Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma

Maurits N. C. de Koning, Soenke Jan Weissenborn, Damiano Abeni, Jan Nico Bouwes Bavinck, Sylvie Euvrard, Adele C. Green, Catherine A. Harwood, Luigi Naldi, Rachel Neale, Ingo Nindl, Charlotte M. Proby, Wim G. V. Quint, Francesca Sampogna, Jan ter Schegget, Linda Struijk, Ulrike Wieland, Herbert J. Pfister, Mariet C. W. Feltkamp, EPI-HPV-UV-CA Grp

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Abstract

    Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91% in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.

    Original languageEnglish
    Pages (from-to)1611-1621
    Number of pages11
    JournalJournal of General Virology
    Volume90
    DOIs
    Publication statusPublished - Jul 2009

    Keywords

    • HUMAN-PAPILLOMAVIRUS DNA
    • RENAL-TRANSPLANT RECIPIENTS
    • NONMELANOMA SKIN-CANCER
    • EPIDERMODYSPLASIA-VERRUCIFORMIS
    • HEALTHY SKIN
    • LESIONS
    • SEROREACTIVITY
    • NETHERLANDS
    • KERATOSES
    • DIVERSITY

    Cite this

    de Koning, M. N. C., Weissenborn, S. J., Abeni, D., Bavinck, J. N. B., Euvrard, S., Green, A. C., Harwood, C. A., Naldi, L., Neale, R., Nindl, I., Proby, C. M., Quint, W. G. V., Sampogna, F., ter Schegget, J., Struijk, L., Wieland, U., Pfister, H. J., Feltkamp, M. C. W., & EPI-HPV-UV-CA Grp (2009). Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. Journal of General Virology, 90, 1611-1621. https://doi.org/10.1099/vir.0.010017-0