TY - JOUR
T1 - Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
AU - de Koning, Maurits N. C.
AU - Weissenborn, Soenke Jan
AU - Abeni, Damiano
AU - Bavinck, Jan Nico Bouwes
AU - Euvrard, Sylvie
AU - Green, Adele C.
AU - Harwood, Catherine A.
AU - Naldi, Luigi
AU - Neale, Rachel
AU - Nindl, Ingo
AU - Proby, Charlotte M.
AU - Quint, Wim G. V.
AU - Sampogna, Francesca
AU - ter Schegget, Jan
AU - Struijk, Linda
AU - Wieland, Ulrike
AU - Pfister, Herbert J.
AU - Feltkamp, Mariet C. W.
AU - EPI-HPV-UV-CA Grp
PY - 2009/7
Y1 - 2009/7
N2 - Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91% in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.
AB - Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91% in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.
KW - HUMAN-PAPILLOMAVIRUS DNA
KW - RENAL-TRANSPLANT RECIPIENTS
KW - NONMELANOMA SKIN-CANCER
KW - EPIDERMODYSPLASIA-VERRUCIFORMIS
KW - HEALTHY SKIN
KW - LESIONS
KW - SEROREACTIVITY
KW - NETHERLANDS
KW - KERATOSES
KW - DIVERSITY
U2 - 10.1099/vir.0.010017-0
DO - 10.1099/vir.0.010017-0
M3 - Article
C2 - 19321753
VL - 90
SP - 1611
EP - 1621
JO - Journal of General Virology
JF - Journal of General Virology
SN - 0022-1317
ER -