TY - JOUR
T1 - Prevalence of common chronic respiratory diseases in drug misusers
T2 - a cohort study
AU - Palmer, Frances
AU - Jaffray, Mariesha
AU - Moffat, Mandy A.
AU - Matheson, Catriona
AU - McLernon, David J.
AU - Coutts, Alasdair
AU - Haughney, John
PY - 2012/8/8
Y1 - 2012/8/8
N2 - Background: A randomised controlled trial of substance misuse indicated that many patients who use methadone have respiratory symptoms and/or are prescribed respiratory medications. There is little research in this area. Aims: To determine the prevalence of respiratory disease and prescriptions among drug misusers. Methods: This historical cohort study of drug misusers and matched controls analysed routinely collected primary care data. The prevalence of common chronic respiratory diseases, class and number of respiratory medications were examined. Results: The cohort of 18,570 patients (9,285 per group) was mostly male (64%, n=11,890) and aged 31-59 years (76%, n=14,060). After adjusting for age, gender, deprivation and smoking status, the results showed that more drug misusers than controls had a diagnosis of asthma or chronic obstructive pulmonary disease (17.1% vs. 10.9%; adjusted odds ratio (OR) 1.61, 95% confidence interval (CI) 1.46 to 1.77, and 2.4% vs. 0.8%; OR 1.86, 95% CI 1.42 to 2.44, respectively) and were prescribed more chronic respiratory medications: short-acting β2-agonists (16.4% vs. 7.9%; OR 2.00, 95% CI 1.80 to 2.22), long-acting β2-agonists (1% vs. 0.4%; OR 1.93, 95% CI 1.29 to 2.89), and inhaled corticosteroids (10.6% vs. 7.6%; OR 1.49, 95% CI 1.33 to 1.67). All differences were statistically significant (p<0.001). Conclusions: Drug misusers have a significantly higher prevalence of respiratory diseases and respiratory prescriptions than matched controls. Further work is needed to determine the reasons for this.
AB - Background: A randomised controlled trial of substance misuse indicated that many patients who use methadone have respiratory symptoms and/or are prescribed respiratory medications. There is little research in this area. Aims: To determine the prevalence of respiratory disease and prescriptions among drug misusers. Methods: This historical cohort study of drug misusers and matched controls analysed routinely collected primary care data. The prevalence of common chronic respiratory diseases, class and number of respiratory medications were examined. Results: The cohort of 18,570 patients (9,285 per group) was mostly male (64%, n=11,890) and aged 31-59 years (76%, n=14,060). After adjusting for age, gender, deprivation and smoking status, the results showed that more drug misusers than controls had a diagnosis of asthma or chronic obstructive pulmonary disease (17.1% vs. 10.9%; adjusted odds ratio (OR) 1.61, 95% confidence interval (CI) 1.46 to 1.77, and 2.4% vs. 0.8%; OR 1.86, 95% CI 1.42 to 2.44, respectively) and were prescribed more chronic respiratory medications: short-acting β2-agonists (16.4% vs. 7.9%; OR 2.00, 95% CI 1.80 to 2.22), long-acting β2-agonists (1% vs. 0.4%; OR 1.93, 95% CI 1.29 to 2.89), and inhaled corticosteroids (10.6% vs. 7.6%; OR 1.49, 95% CI 1.33 to 1.67). All differences were statistically significant (p<0.001). Conclusions: Drug misusers have a significantly higher prevalence of respiratory diseases and respiratory prescriptions than matched controls. Further work is needed to determine the reasons for this.
KW - Adherence
KW - Cohort study
KW - Compliance
KW - Drug users
KW - Respiratory disease
KW - Substance misuse
UR - http://www.scopus.com/inward/record.url?scp=84870923089&partnerID=8YFLogxK
U2 - 10.4104/pcrj.2012.00069
DO - 10.4104/pcrj.2012.00069
M3 - Article
C2 - 22875144
AN - SCOPUS:84870923089
VL - 21
SP - 377
EP - 383
JO - Primary Care Respiratory Journal
JF - Primary Care Respiratory Journal
SN - 1471-4418
IS - 4
ER -
