Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

PHOSP-COVID Collaborative Group; Camilla Dawson; Gemma Clunie; Felicity Evison; Sallyanne Duncan; Julie Whitney; Linzy Houchen-Wolloff; Charlotte E. Bolton; Olivia C. Leavy; Matthew Richardson; Elneima Omer; Hamish McAuley; Aarti Shikotra; Amisha Singapuri; Marco Sereno; Ruth M. Saunders; Victoria C. Harris; Neil J. Greening; Claire Marie Nolan; Dan Gower Wootton; Enya Daynes; Gavin Donaldson; Jack Sargent; Janet Scott; John Pimm; Lettie Bishop; Melitta McNarry; Nicholas Hart; Rachael A. Evans; Sally Singh; Tom Yates; Trudie Chalder; William Man; Ewen Harrison; Annemarie Docherty; Nazir I. Lone; Jennifer K. Quint; James Chalmers; Ling-Pei Ho; Alex Robert Horsley; Michael Marks; Krisnah Poinasamy; Betty Raman; Louise V. Wain; Chris Brightling; Neil Sharma; Margaret Coffey; Amit Kulkarni; Sarah Wallace

doi:10.1136/bmjresp-2023-001647

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

PHOSP-COVID Collaborative Group, Camilla Dawson (Lead / Corresponding author), Gemma Clunie, Felicity Evison, Sallyanne Duncan, Julie Whitney, Linzy Houchen-Wolloff, Charlotte E. Bolton, Olivia C. Leavy, Matthew Richardson, Elneima Omer, Hamish McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Neil J. Greening, Claire Marie Nolan, Dan Gower WoottonEnya Daynes, Gavin Donaldson, Jack Sargent, Janet Scott, John Pimm, Lettie Bishop, Melitta McNarry, Nicholas Hart, Rachael A. Evans, Sally Singh, Tom Yates, Trudie Chalder, William Man, Ewen Harrison, Annemarie Docherty, Nazir I. Lone, Jennifer K. Quint, James Chalmers, Ling-Pei Ho, Alex Robert Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise V. Wain, Chris Brightling, Neil Sharma, Margaret Coffey, Amit Kulkarni, Sarah Wallace

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.

Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2-7 months post discharge) and visit 2 (10-14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.

Setting: 64 UK acute hospital Trusts.

Participants: Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.

Main outcome measures: Self-reported swallow, communication, voice and cognitive compromise.

Results: Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).

Conclusion: Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.

Original language	English
Article number	e001647
Number of pages	17
Journal	BMJ Open Respiratory Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1136/bmjresp-2023-001647
Publication status	Published - 26 Jul 2023

Keywords

Adult
Female
Humans
Aftercare
Cognition
Communication
COVID-19/epidemiology
Hospitalization
Patient Discharge
Prevalence
Prospective Studies
Male

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10.1136/bmjresp-2023-001647Licence: CC BY-NC

Final Published VersionFinal published version, 1.19 MBLicence: CC BY-NC

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PHOSP-COVID Collaborative Group, Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., Bolton, C. E., Leavy, O. C., Richardson, M., Omer, E., McAuley, H., Shikotra, A., Singapuri, A., Sereno, M., Saunders, R. M., Harris, V. C., Greening, N. J., Nolan, C. M., ... Wallace, S. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ Open Respiratory Research, 10(1), Article e001647. https://doi.org/10.1136/bmjresp-2023-001647

@article{54d61556480640bd8cbffc37cb510cdf,

title = "Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis",

abstract = "Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2-7 months post discharge) and visit 2 (10-14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.Setting: 64 UK acute hospital Trusts.Participants: Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.Main outcome measures: Self-reported swallow, communication, voice and cognitive compromise.Results: Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).Conclusion: Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.",

keywords = "Adult, Female, Humans, Aftercare, Cognition, Communication, COVID-19/epidemiology, Hospitalization, Patient Discharge, Prevalence, Prospective Studies, Male",

author = "{PHOSP-COVID Collaborative Group} and Camilla Dawson and Gemma Clunie and Felicity Evison and Sallyanne Duncan and Julie Whitney and Linzy Houchen-Wolloff and Bolton, {Charlotte E.} and Leavy, {Olivia C.} and Matthew Richardson and Elneima Omer and Hamish McAuley and Aarti Shikotra and Amisha Singapuri and Marco Sereno and Saunders, {Ruth M.} and Harris, {Victoria C.} and Greening, {Neil J.} and Nolan, {Claire Marie} and {Gower Wootton}, Dan and Enya Daynes and Gavin Donaldson and Jack Sargent and Janet Scott and John Pimm and Lettie Bishop and Melitta McNarry and Nicholas Hart and Evans, {Rachael A.} and Sally Singh and Tom Yates and Trudie Chalder and William Man and Ewen Harrison and Annemarie Docherty and Lone, {Nazir I.} and Quint, {Jennifer K.} and James Chalmers and Ling-Pei Ho and Horsley, {Alex Robert} and Michael Marks and Krisnah Poinasamy and Betty Raman and Wain, {Louise V.} and Chris Brightling and Neil Sharma and Margaret Coffey and Amit Kulkarni and Sarah Wallace and Jacob George",

note = "Funding Information: PHOSP-COVID is jointly funded by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 (grant references: MR/V027859/1 and COV0319). Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2023",

month = jul,

day = "26",

doi = "10.1136/bmjresp-2023-001647",

language = "English",

volume = "10",

journal = "BMJ Open Respiratory Research",

issn = "2052-4439",

publisher = "BMJ Publishing Group",

number = "1",

}

PHOSP-COVID Collaborative Group, Dawson, C, Clunie, G, Evison, F, Duncan, S, Whitney, J, Houchen-Wolloff, L, Bolton, CE, Leavy, OC, Richardson, M, Omer, E, McAuley, H, Shikotra, A, Singapuri, A, Sereno, M, Saunders, RM, Harris, VC, Greening, NJ, Nolan, CM, Gower Wootton, D, Daynes, E, Donaldson, G, Sargent, J, Scott, J, Pimm, J, Bishop, L, McNarry, M, Hart, N, Evans, RA, Singh, S, Yates, T, Chalder, T, Man, W, Harrison, E, Docherty, A, Lone, NI, Quint, JK, Chalmers, J, Ho, L-P, Horsley, AR, Marks, M, Poinasamy, K, Raman, B, Wain, LV, Brightling, C, Sharma, N, Coffey, M, Kulkarni, A & Wallace, S 2023, 'Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis', BMJ Open Respiratory Research, vol. 10, no. 1, e001647. https://doi.org/10.1136/bmjresp-2023-001647

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. / PHOSP-COVID Collaborative Group; Dawson, Camilla (Lead / Corresponding author); Clunie, Gemma et al.
In: BMJ Open Respiratory Research, Vol. 10, No. 1, e001647, 26.07.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19

T2 - the PHOSP-COVID analysis

AU - PHOSP-COVID Collaborative Group

AU - Dawson, Camilla

AU - Clunie, Gemma

AU - Evison, Felicity

AU - Duncan, Sallyanne

AU - Whitney, Julie

AU - Houchen-Wolloff, Linzy

AU - Bolton, Charlotte E.

AU - Leavy, Olivia C.

AU - Richardson, Matthew

AU - Omer, Elneima

AU - McAuley, Hamish

AU - Shikotra, Aarti

AU - Singapuri, Amisha

AU - Sereno, Marco

AU - Saunders, Ruth M.

AU - Harris, Victoria C.

AU - Greening, Neil J.

AU - Nolan, Claire Marie

AU - Gower Wootton, Dan

AU - Daynes, Enya

AU - Donaldson, Gavin

AU - Sargent, Jack

AU - Scott, Janet

AU - Pimm, John

AU - Bishop, Lettie

AU - McNarry, Melitta

AU - Hart, Nicholas

AU - Evans, Rachael A.

AU - Singh, Sally

AU - Yates, Tom

AU - Chalder, Trudie

AU - Man, William

AU - Harrison, Ewen

AU - Docherty, Annemarie

AU - Lone, Nazir I.

AU - Quint, Jennifer K.

AU - Chalmers, James

AU - Ho, Ling-Pei

AU - Horsley, Alex Robert

AU - Marks, Michael

AU - Poinasamy, Krisnah

AU - Raman, Betty

AU - Wain, Louise V.

AU - Brightling, Chris

AU - Sharma, Neil

AU - Coffey, Margaret

AU - Kulkarni, Amit

AU - Wallace, Sarah

AU - George, Jacob

N1 - Funding Information: PHOSP-COVID is jointly funded by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19 (grant references: MR/V027859/1 and COV0319). Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2023/7/26

Y1 - 2023/7/26

N2 - Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2-7 months post discharge) and visit 2 (10-14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.Setting: 64 UK acute hospital Trusts.Participants: Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.Main outcome measures: Self-reported swallow, communication, voice and cognitive compromise.Results: Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).Conclusion: Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.

AB - Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2-7 months post discharge) and visit 2 (10-14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.Setting: 64 UK acute hospital Trusts.Participants: Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.Main outcome measures: Self-reported swallow, communication, voice and cognitive compromise.Results: Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).Conclusion: Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.

KW - Adult

KW - Female

KW - Humans

KW - Aftercare

KW - Cognition

KW - Communication

KW - COVID-19/epidemiology

KW - Hospitalization

KW - Patient Discharge

KW - Prevalence

KW - Prospective Studies

KW - Male

UR - http://www.scopus.com/inward/record.url?scp=85165873858&partnerID=8YFLogxK

U2 - 10.1136/bmjresp-2023-001647

DO - 10.1136/bmjresp-2023-001647

M3 - Article

C2 - 37495260

SN - 2052-4439

VL - 10

JO - BMJ Open Respiratory Research

JF - BMJ Open Respiratory Research

IS - 1

M1 - e001647

ER -

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

Abstract

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PHOS-COVID (Joint with University of Leicester)

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Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

Abstract

Keywords

Access to Document

Other files and links

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Projects

PHOS-COVID (Joint with University of Leicester)

Cite this