Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

Sara J. Brown, Aileen Sandilands, Yiwei Zhao, Haihui Liao, Caroline L. Relton, Simon J. Meggitt, Richard C. Trembath, Jonathan N. W. N. Barker, Nick J. Reynolds, Heather J. Cordell, W. H. Irwin McLean

    Research output: Contribution to journalLetterpeer-review

    87 Citations (Scopus)
    Original languageEnglish
    Pages (from-to)1591-1594
    Number of pages5
    JournalJournal of Investigative Dermatology
    Issue number6
    Early online date20 Dec 2007
    Publication statusPublished - Jun 2008


    • Cause ichthyosis vulgaris
    • Epidermal differentiation
    • Rare mutations
    • Dermatitis
    • Skin

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