Prevention/treatment of ichthyosis vulgaris, atopy and other disorders

William Henry Irwin McLean (Inventor), Frances Jan Dorothy Smith (Inventor)

    Research output: Patent


    The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.
    Original languageEnglish
    Patent numberWO/2007/083094
    IPCC07K 14/47 (2006.01), A61K 31/7036 (2006.01), A61K 48/00 (2006.01), C12Q 1/68 (2006.01)
    Publication statusPublished - 26 Jul 2007


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