Primary afferent-evoked release of immunoreactive galanin in the spinal cord of the neuropathic rat

L. A. Colvin (Lead / Corresponding author), A. W. Duggan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have determined if peripheral nerve stimulation altered the increased spontaneous release of immunoreactive (ir)-galanin that is found in the superficial dorsal horn of the spinal cord of neuropathic rats. Using the antibody microprobe technique to study the localized sites of ir-galanin release in vivo, we found that high intensity electrical stimulation of the injured nerve resulted in a further increase in ir-galanin release in the superficial dorsal horn, with no significant persistence of ir-galanin after release. Release of ir-galanin at stimulus strengths sufficient to activate C fibres, in an area of the spinal cord thought to be concerned with nociceptive transmission, indicates a possible role for this peptide in the spinal modulation of pain after peripheral nerve injury.

Original languageEnglish
Pages (from-to)436-443
Number of pages8
JournalBritish Journal of Anaesthesia
Volume81
Issue number3
DOIs
Publication statusPublished - Sep 1998

Keywords

  • Model, rat
  • Pain, experimental
  • Pain, neuropathic
  • Rat
  • Spinal cord, galanin

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