Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase

Andrew J. Garton, David G. Campbell, Philip Cohen, Stephen J. Yeaman

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The primary structure of a region on hormone-sensitive lipase was determined to be: Lys-Thr-Glu-Pro-Met-Arg-Arg-Ser-Val-Ser-Glu-Ala-Ala-Leu-Thr-Gln-Pro-Glu-Gly-Pro-Leu-Gly-Thr-Asp-Ser-Leu-Lys. Ser-8 was the only residue in the intact protein phosphorylated by cyclic AMP-dependent protein kinase. However, Ser-10 also appeared to be present in a phosphorylated form, suggesting that it is a target for a distinct protein kinase in vivo.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalFEBS Letters
Volume229
Issue number1
DOIs
Publication statusPublished - 29 Feb 1988

Keywords

  • Amino acid sequence
  • cyclic AMP
  • Hormone-sensitive lipase
  • Protein kinase
  • Protein phosphorylation

Fingerprint Dive into the research topics of 'Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase'. Together they form a unique fingerprint.

  • Cite this