Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase

TY - JOUR

T1 - Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase

AU - Garton, Andrew J.

AU - Campbell, David G.

AU - Cohen, Philip

AU - Yeaman, Stephen J.

PY - 1988/2/29

Y1 - 1988/2/29

N2 - The primary structure of a region on hormone-sensitive lipase was determined to be: Lys-Thr-Glu-Pro-Met-Arg-Arg-Ser-Val-Ser-Glu-Ala-Ala-Leu-Thr-Gln-Pro-Glu-Gly-Pro-Leu-Gly-Thr-Asp-Ser-Leu-Lys. Ser-8 was the only residue in the intact protein phosphorylated by cyclic AMP-dependent protein kinase. However, Ser-10 also appeared to be present in a phosphorylated form, suggesting that it is a target for a distinct protein kinase in vivo.

AB - The primary structure of a region on hormone-sensitive lipase was determined to be: Lys-Thr-Glu-Pro-Met-Arg-Arg-Ser-Val-Ser-Glu-Ala-Ala-Leu-Thr-Gln-Pro-Glu-Gly-Pro-Leu-Gly-Thr-Asp-Ser-Leu-Lys. Ser-8 was the only residue in the intact protein phosphorylated by cyclic AMP-dependent protein kinase. However, Ser-10 also appeared to be present in a phosphorylated form, suggesting that it is a target for a distinct protein kinase in vivo.

KW - Amino acid sequence

KW - cyclic AMP

KW - Hormone-sensitive lipase

KW - Protein kinase

KW - Protein phosphorylation

UR - https://www.scopus.com/pages/publications/0023853732

U2 - 10.1016/0014-5793(88)80799-3

DO - 10.1016/0014-5793(88)80799-3

M3 - Article

C2 - 3345839

AN - SCOPUS:0023853732

SN - 0014-5793

VL - 229

SP - 68

EP - 72

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -