Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes

Joel Rocha (Lead / Corresponding author), Norita Gildea (Lead / Corresponding author), Donal O'Shea, Simon Green, Mikel Egaña (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
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Abstract

Background: The primary phase time constant of pulmonary oxygen uptake kinetics (V̇O2 τp) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply to active muscles. This study examined if a high-intensity "priming" exercise (PE) would speed V̇O2 τp during a subsequent high-intensity cycling exercise in T2D due to enhanced oxygen delivery.
Methods: Eleven (4 women) middle-aged individuals with type 2 diabetes and 11 (4 women) non-diabetic controls completed four separate cycling bouts each starting at an 'unloaded' baseline of 10 W and transitioning to a high-intensity constant-load. Two of the four cycling bouts were preceded by priming exercise. The dynamics of pulmonary V̇O2 and muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration [HHb + Mb]), were calculated from breath-by-breath and near-infrared spectroscopy data at the vastus lateralis, respectively.
Results: At baseline V̇O2 τp, was slower (p < 0.001) in the type 2 diabetes group (48 ± 6s) compared to the control group (34 ± 2s) but priming exercise significantly reduced V̇O2 τp (p < 0.001) in type 2 diabetes (32 ± 6s) so that post priming exercise it was not different compared with controls (34 ± 3s). Priming exercise reduced the amplitude of the V̇O2 slow component (As) in both groups (type 2 diabetes: 0.26 ± 0.11 to 0.16 ± 0.07 L/min; control: 0.33 ± 0.13 to 0.25 ± 0.14 L/min, p < 0.001), while [HHb + Mb] kinetics remained unchanged.
Conclusion: These results suggest that in middle-aged men and women withT2D, PE speeds V̇Oτp likely by a better matching of O2 delivery to utilisation and reduces the V̇OAs during a subsequent high-intensity exercise. 
Original languageEnglish
Article number1006993
Number of pages12
JournalFrontiers in Physiology
Volume13
DOIs
Publication statusPublished - 18 Nov 2022

Keywords

  • near-infrared spectroscopy
  • oxygen extraction
  • cycling
  • exercise tolerance
  • oxygen uptake slow component

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