Principles of focused ultrasound

Senay Mihcin, Andreas Melzer (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    21 Citations (Scopus)
    398 Downloads (Pure)


    Focused ultrasound (FUS/HIFU) relies on ablation of pathological tissues, by delivering sufficiently high level of acoustic energy in situ of the human body. Magnetic Resonance guided FUS (MRgFUS/HIFU) and Ultrasound guided (USgFUS/HIFU) are image guided techniques combined with therapeutic FUS for monitoring purposes. The principles and technologies of FUS/HiFU are described in this paper including the basics of MR guidance techniques and MR temperature mapping. Clinical applications FUS/HIFU gained CE and FDA approvals for the treatment of various benign and few malignant lesions in the last two decades. Current technical limitations of ultrasound guided and MRI guided Focused Ultrasound, as well as adverse effects for the application of this technique is outlined including challenges of ablating moving organs (Liver and Kidney). An outlook to possible applications is provided; exampling clinical trials discussing future options.
    Original languageEnglish
    Pages (from-to)41-50
    Number of pages10
    JournalMinimally Invasive Therapy and Allied Technologies
    Issue number1
    Early online date18 Jan 2018
    Publication statusPublished - Jan 2018


    • FUS
    • HiFU
    • MR guided focused ultrasound
    • MRHiFU
    • MRgFUS
    • focused ultrasound
    • high intensity focused ultrasound
    • liver ablation
    • sonication of moving organs

    ASJC Scopus subject areas

    • Surgery


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