Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol

Brian J. Lipworth; Denis G. McDevitt; Allan D. Struthers

doi:10.1016/0002-9343(89)90438-5

Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol

Brian J. Lipworth, Denis G. McDevitt, Allan D. Struthers

Research output: Contribution to journal › Article › peer-review

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Abstract

High doses of inhaled albuterol produce substantial improvements in bronchodilatation but are associated with dose-related systemic side effects including hypokalemia and hypomagnesemia. Concomitant diuretic therapy also produces these metabolic sequelae and may therefore precipitate cardiac arrhythmias in patients taking this combination of drugs. The purpose of this study was to investigate the electrocardiographic (ECG) effects of high-dose inhaled albuterol, and to evaluate whether potentiation occurs with bendrofluazide.

Original language	English
Pages (from-to)	653-657
Number of pages	5
Journal	American Journal of Medicine
Volume	86
Issue number	6
DOIs	https://doi.org/10.1016/0002-9343(89)90438-5
Publication status	Published - 1989

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10.1016/0002-9343(89)90438-5

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title = "Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol",

abstract = "High doses of inhaled albuterol produce substantial improvements in bronchodilatation but are associated with dose-related systemic side effects including hypokalemia and hypomagnesemia. Concomitant diuretic therapy also produces these metabolic sequelae and may therefore precipitate cardiac arrhythmias in patients taking this combination of drugs. The purpose of this study was to investigate the electrocardiographic (ECG) effects of high-dose inhaled albuterol, and to evaluate whether potentiation occurs with bendrofluazide.",

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AU - McDevitt, Denis G.

AU - Struthers, Allan D.

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AB - High doses of inhaled albuterol produce substantial improvements in bronchodilatation but are associated with dose-related systemic side effects including hypokalemia and hypomagnesemia. Concomitant diuretic therapy also produces these metabolic sequelae and may therefore precipitate cardiac arrhythmias in patients taking this combination of drugs. The purpose of this study was to investigate the electrocardiographic (ECG) effects of high-dose inhaled albuterol, and to evaluate whether potentiation occurs with bendrofluazide.

U2 - 10.1016/0002-9343(89)90438-5

DO - 10.1016/0002-9343(89)90438-5

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EP - 657

JO - American Journal of Medicine

JF - American Journal of Medicine

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Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol

Abstract

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