Probiotics in Extraintestinal Diseases: Current Trends and New Directions

Despoina E. Kiousi, Athanasios Karapetsas, Kyriaki Karolidou, Mihalis I. Panayiotidis, Aglaia Pappa, Alex Galanis (Lead / Corresponding author)

Research output: Contribution to journalReview article

3 Citations (Scopus)
61 Downloads (Pure)

Abstract

Probiotics are defined as live microorganisms that when administered in adequate amounts confer a health benefit to the host. Their positive supplementation outcomes on several gastrointestinal disorders are well defined. Nevertheless, their actions are not limited to the gut, but may also impart their beneficial effects at distant sites and organs. In this regard, in this review article we: (i) comprehensively describe the main mechanisms of action of probiotics at distant sites, including bones, skin, and brain; (ii) critically present their therapeutic potential against bone, skin, and neuronal diseases (e.g., osteoporosis, non-healing wounds and autoimmune skin illnesses, mood, behavior, memory, and cognitive impairments); (iii) address the current gaps in the preclinical and clinical research; and (iv) indicate new research directions and suggest future investigations.

Original languageEnglish
Article number788
Pages (from-to)1-26
Number of pages26
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 5 Apr 2019

Fingerprint

Probiotics
skin (animal)
probiotics
Illness Behavior
Bone and Bones
Skin
Insurance Benefits
Research
Skin Diseases
bones
Osteoporosis
osteoporosis
emotions
digestive system diseases
animal injuries
mechanism of action
Wounds and Injuries
Brain
digestive system
microorganisms

Keywords

  • Bone
  • Gastrointestinal
  • Microbiota
  • Neuronal disease
  • Probiotics
  • Skin

Cite this

Kiousi, D. E., Karapetsas, A., Karolidou, K., Panayiotidis, M. I., Pappa, A., & Galanis, A. (2019). Probiotics in Extraintestinal Diseases: Current Trends and New Directions. Nutrients, 11(4), 1-26. [788]. https://doi.org/10.3390/nu11040788
Kiousi, Despoina E. ; Karapetsas, Athanasios ; Karolidou, Kyriaki ; Panayiotidis, Mihalis I. ; Pappa, Aglaia ; Galanis, Alex. / Probiotics in Extraintestinal Diseases : Current Trends and New Directions. In: Nutrients. 2019 ; Vol. 11, No. 4. pp. 1-26.
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Kiousi, DE, Karapetsas, A, Karolidou, K, Panayiotidis, MI, Pappa, A & Galanis, A 2019, 'Probiotics in Extraintestinal Diseases: Current Trends and New Directions', Nutrients, vol. 11, no. 4, 788, pp. 1-26. https://doi.org/10.3390/nu11040788

Probiotics in Extraintestinal Diseases : Current Trends and New Directions. / Kiousi, Despoina E.; Karapetsas, Athanasios; Karolidou, Kyriaki; Panayiotidis, Mihalis I.; Pappa, Aglaia; Galanis, Alex (Lead / Corresponding author).

In: Nutrients, Vol. 11, No. 4, 788, 05.04.2019, p. 1-26.

Research output: Contribution to journalReview article

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Kiousi DE, Karapetsas A, Karolidou K, Panayiotidis MI, Pappa A, Galanis A. Probiotics in Extraintestinal Diseases: Current Trends and New Directions. Nutrients. 2019 Apr 5;11(4):1-26. 788. https://doi.org/10.3390/nu11040788