Probucol, a superoxide free radical scavenger in vitro

A.B. Bridges, N.A. Scott, J.J.F. Belch

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported. We therefore studied the FR scavenging properties of probucol in vitro and results show that this drug is a powerful superoxide scavenger. This property may be relevant in its use as a lipid lowering drug in the retardation of the atherosclerotic process.
    Original languageEnglish
    Pages (from-to)263-265
    Number of pages3
    JournalAtherosclerosis
    Volume89
    Issue number2-3
    DOIs
    Publication statusPublished - Aug 1991

    Fingerprint Dive into the research topics of 'Probucol, a superoxide free radical scavenger in vitro'. Together they form a unique fingerprint.

    Cite this