Probucol, a superoxide free radical scavenger in vitro

A.B. Bridges; N.A. Scott; J.J.F. Belch

doi:10.1016/0021-9150(91)90068-E

Probucol, a superoxide free radical scavenger in vitro

A.B. Bridges, N.A. Scott, J.J.F. Belch

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Abstract

Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported. We therefore studied the FR scavenging properties of probucol in vitro and results show that this drug is a powerful superoxide scavenger. This property may be relevant in its use as a lipid lowering drug in the retardation of the atherosclerotic process.

Original language	English
Pages (from-to)	263-265
Number of pages	3
Journal	Atherosclerosis
Volume	89
Issue number	2-3
DOIs	https://doi.org/10.1016/0021-9150(91)90068-E
Publication status	Published - Aug 1991

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http://www.atherosclerosis-journal.com/article/0021-9150%2891%2990068-E/abstract

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title = "Probucol, a superoxide free radical scavenger in vitro",

abstract = "Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported. We therefore studied the FR scavenging properties of probucol in vitro and results show that this drug is a powerful superoxide scavenger. This property may be relevant in its use as a lipid lowering drug in the retardation of the atherosclerotic process.",

author = "A.B. Bridges and N.A. Scott and J.J.F. Belch",

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AU - Bridges, A.B.

AU - Scott, N.A.

AU - Belch, J.J.F.

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Y1 - 1991/8

N2 - Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported. We therefore studied the FR scavenging properties of probucol in vitro and results show that this drug is a powerful superoxide scavenger. This property may be relevant in its use as a lipid lowering drug in the retardation of the atherosclerotic process.

AB - Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported. We therefore studied the FR scavenging properties of probucol in vitro and results show that this drug is a powerful superoxide scavenger. This property may be relevant in its use as a lipid lowering drug in the retardation of the atherosclerotic process.

U2 - 10.1016/0021-9150(91)90068-E

DO - 10.1016/0021-9150(91)90068-E

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VL - 89

SP - 263

EP - 265

JO - Atherosclerosis

JF - Atherosclerosis

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Probucol, a superoxide free radical scavenger in vitro

Abstract

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