Proceedings of the 4thBEAT-PCD Conference and 5thPCD Training School

Laura E. Gardner; Katie L. Horton; Amelia Shoemark; Jane S. Lucas; Kim G. Nielsen; Helene Kobbernagel; Bruna Rubbo; Robert A. Hirst; Panayiotis Kouis; Nicola Ullmann; Ana Reula; Nisreen Rumman; Hannah M. Mitchison; Andreia Pinto; Charlotte Richardson; Anne Schmidt; James Thompson; René Gaupmann; Maciej Dabrowski; Pleasantine Mill; Siobhan B. Carr; Dominic P. Norris; Claudia E. Kuehni; Myrofora Goutaki; Claire Hogg

doi:10.1186/s12919-020-00191-3

Proceedings of the 4^thBEAT-PCD Conference and 5^thPCD Training School

Laura E. Gardner
, Katie L. Horton
, Amelia Shoemark
, Jane S. Lucas
, Kim G. Nielsen
, Helene Kobbernagel
, Bruna Rubbo
, Robert A. Hirst
, Panayiotis Kouis
, Nicola Ullmann
, Ana Reula
, Nisreen Rumman
, Hannah M. Mitchison
, Andreia Pinto
, Charlotte Richardson
, Anne Schmidt
, James Thompson
, René Gaupmann
, Maciej Dabrowski
, Pleasantine Mill

Siobhan B. Carr, Dominic P. Norris, Claudia E. Kuehni, Myrofora Goutaki, Claire Hogg (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

144 Downloads (Pure)

Abstract

Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and situs abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. 'Better Experimental Approaches to Treat Primary Ciliary Dyskinesia' (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world to drive advances in the field. The fourth and final BEAT-PCD Conference and fifth PCD Training School were held jointly in March 2019 in Poznan, Poland. The varied program of plenaries, workshops, break-out sessions, oral and poster presentations were aimed to enhance the knowledge and skills of delegates, whilst also providing a collaborative platform to exchange ideas. In this final BEAT-PCD conference we were able to build upon programmes developed throughout the lifetime of the COST Action. These proceedings report on the conference, highlighting some of the successes of the BEAT-PCD programme.

Original language	English
Article number	7
Pages (from-to)	1-17
Number of pages	17
Journal	BMC Proceedings
Volume	14
Issue number	Suppl. 8
Early online date	19 Jun 2020
DOIs	https://doi.org/10.1186/s12919-020-00191-3
Publication status	Published - 19 Jun 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic respiratory disease
Multidisciplinary
Primary ciliary dyskinesia

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1186/s12919-020-00191-3

Publisher Final Version
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Final published version, 855 KBLicence: CC BY

Cite this

Gardner, L. E., Horton, K. L., Shoemark, A., Lucas, J. S., Nielsen, K. G., Kobbernagel, H., Rubbo, B., Hirst, R. A., Kouis, P., Ullmann, N., Reula, A., Rumman, N., Mitchison, H. M., Pinto, A., Richardson, C., Schmidt, A., Thompson, J., Gaupmann, R., Dabrowski, M., ... Hogg, C. (2020). Proceedings of the 4^thBEAT-PCD Conference and 5^thPCD Training School. BMC Proceedings, 14(Suppl. 8), 1-17. Article 7. https://doi.org/10.1186/s12919-020-00191-3

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abstract = "Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and situs abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. 'Better Experimental Approaches to Treat Primary Ciliary Dyskinesia' (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world to drive advances in the field. The fourth and final BEAT-PCD Conference and fifth PCD Training School were held jointly in March 2019 in Poznan, Poland. The varied program of plenaries, workshops, break-out sessions, oral and poster presentations were aimed to enhance the knowledge and skills of delegates, whilst also providing a collaborative platform to exchange ideas. In this final BEAT-PCD conference we were able to build upon programmes developed throughout the lifetime of the COST Action. These proceedings report on the conference, highlighting some of the successes of the BEAT-PCD programme.",

keywords = "Chronic respiratory disease, Multidisciplinary, Primary ciliary dyskinesia",

author = "Gardner, \{Laura E.\} and Horton, \{Katie L.\} and Amelia Shoemark and Lucas, \{Jane S.\} and Nielsen, \{Kim G.\} and Helene Kobbernagel and Bruna Rubbo and Hirst, \{Robert A.\} and Panayiotis Kouis and Nicola Ullmann and Ana Reula and Nisreen Rumman and Mitchison, \{Hannah M.\} and Andreia Pinto and Charlotte Richardson and Anne Schmidt and James Thompson and Ren{\'e} Gaupmann and Maciej Dabrowski and Pleasantine Mill and Carr, \{Siobhan B.\} and Norris, \{Dominic P.\} and Kuehni, \{Claudia E.\} and Myrofora Goutaki and Claire Hogg",

note = "Funding Information: BESTCILIA was a research programme funded by the European Commission 7th Framework Programme which preceded BEAT-PCD. The initial results of the highly anticipated phase III RCT of azithromycin maintenance therapy were presented by Helene Kobbernagel and Kim G Nielsen. This double-blind, parallel group study is the first multinational pharmacotherapy RCT in PCD and it aimed to examine the efficacy and safety of azithromycin maintenance therapy for 6 months, compared to placebo [49]. Despite being slightly underpowered for the primary outcome, the results were promising regarding exacerbations. At the time of the conference further analyses were ongoing and publication was pending. The study, together with the previous trial on hypertonic saline, again highlights that recruitment is challenging in this rare disease and therefore a multinational collaborative approach is required [79, 80]. Funding Information: This meeting and this publication were funded by BEAT-PCD (COST Action BM 1407); BEAT-PCD is funded by COST through European Framework Horizon 2020 support. Education grants to further support activities at the meeting were awarded by Circassia. Local funding that contributed to the running of the conference itself was received from the Polish Academy of Science (Poland) and the Poznan City Hall. As noted above, Maciej Dabrowski received funding from the Polish National Science Centre 2016/23/N/NZ4/ 03228 for his project. Publisher Copyright: {\textcopyright} 2020 The Author(s).",

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doi = "10.1186/s12919-020-00191-3",

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Gardner, LE, Horton, KL, Shoemark, A, Lucas, JS, Nielsen, KG, Kobbernagel, H, Rubbo, B, Hirst, RA, Kouis, P, Ullmann, N, Reula, A, Rumman, N, Mitchison, HM, Pinto, A, Richardson, C, Schmidt, A, Thompson, J, Gaupmann, R, Dabrowski, M, Mill, P, Carr, SB, Norris, DP, Kuehni, CE, Goutaki, M & Hogg, C 2020, 'Proceedings of the 4^thBEAT-PCD Conference and 5^thPCD Training School', BMC Proceedings, vol. 14, no. Suppl. 8, 7, pp. 1-17. https://doi.org/10.1186/s12919-020-00191-3

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T1 - Proceedings of the 4thBEAT-PCD Conference and 5thPCD Training School

AU - Gardner, Laura E.

AU - Horton, Katie L.

AU - Shoemark, Amelia

AU - Lucas, Jane S.

AU - Nielsen, Kim G.

AU - Kobbernagel, Helene

AU - Rubbo, Bruna

AU - Hirst, Robert A.

AU - Kouis, Panayiotis

AU - Ullmann, Nicola

AU - Reula, Ana

AU - Rumman, Nisreen

AU - Mitchison, Hannah M.

AU - Pinto, Andreia

AU - Richardson, Charlotte

AU - Schmidt, Anne

AU - Thompson, James

AU - Gaupmann, René

AU - Dabrowski, Maciej

AU - Mill, Pleasantine

AU - Carr, Siobhan B.

AU - Norris, Dominic P.

AU - Kuehni, Claudia E.

AU - Goutaki, Myrofora

AU - Hogg, Claire

N1 - Funding Information: BESTCILIA was a research programme funded by the European Commission 7th Framework Programme which preceded BEAT-PCD. The initial results of the highly anticipated phase III RCT of azithromycin maintenance therapy were presented by Helene Kobbernagel and Kim G Nielsen. This double-blind, parallel group study is the first multinational pharmacotherapy RCT in PCD and it aimed to examine the efficacy and safety of azithromycin maintenance therapy for 6 months, compared to placebo [49]. Despite being slightly underpowered for the primary outcome, the results were promising regarding exacerbations. At the time of the conference further analyses were ongoing and publication was pending. The study, together with the previous trial on hypertonic saline, again highlights that recruitment is challenging in this rare disease and therefore a multinational collaborative approach is required [79, 80]. Funding Information: This meeting and this publication were funded by BEAT-PCD (COST Action BM 1407); BEAT-PCD is funded by COST through European Framework Horizon 2020 support. Education grants to further support activities at the meeting were awarded by Circassia. Local funding that contributed to the running of the conference itself was received from the Polish Academy of Science (Poland) and the Poznan City Hall. As noted above, Maciej Dabrowski received funding from the Polish National Science Centre 2016/23/N/NZ4/ 03228 for his project. Publisher Copyright: © 2020 The Author(s).

PY - 2020/6/19

Y1 - 2020/6/19

N2 - Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and situs abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. 'Better Experimental Approaches to Treat Primary Ciliary Dyskinesia' (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world to drive advances in the field. The fourth and final BEAT-PCD Conference and fifth PCD Training School were held jointly in March 2019 in Poznan, Poland. The varied program of plenaries, workshops, break-out sessions, oral and poster presentations were aimed to enhance the knowledge and skills of delegates, whilst also providing a collaborative platform to exchange ideas. In this final BEAT-PCD conference we were able to build upon programmes developed throughout the lifetime of the COST Action. These proceedings report on the conference, highlighting some of the successes of the BEAT-PCD programme.

AB - Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and situs abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. 'Better Experimental Approaches to Treat Primary Ciliary Dyskinesia' (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world to drive advances in the field. The fourth and final BEAT-PCD Conference and fifth PCD Training School were held jointly in March 2019 in Poznan, Poland. The varied program of plenaries, workshops, break-out sessions, oral and poster presentations were aimed to enhance the knowledge and skills of delegates, whilst also providing a collaborative platform to exchange ideas. In this final BEAT-PCD conference we were able to build upon programmes developed throughout the lifetime of the COST Action. These proceedings report on the conference, highlighting some of the successes of the BEAT-PCD programme.

KW - Chronic respiratory disease

KW - Multidisciplinary

KW - Primary ciliary dyskinesia

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