Professional presentation of antigen by activated human T cells

Vincenzo Barnaba, Colin Watts, Mark de Boer, Peter Lane, Antonio Lanzavecchia

    Research output: Contribution to journalArticlepeer-review

    112 Citations (Scopus)

    Abstract

    Activated human T cells express class II molecules, but their capacity to present soluble antigens and stimulate T cells has been repeatedly questioned. Two lines of evidence indicate that T cells may indeed function as professional antigen‐presenting cells. First, T cells that have been recently activated can efficiently capture, process and present tetanus toxoid to class II‐restricted T cell clones. This capacity correlates with the rate of class II synthesis. Second, activated T cell clones express high levels of B7, are powerful stimulators in mixed lymphocyte reactions, and their stumulatory capacity is inhibited by soluble CTLA4 or anti‐B7 antibody. Furthermore, expression of B7 can be detected in vivo on T cells from biopsies of patients with liver disease. Presentation of soluble antigen by activated T cells may play a role in the amplification of the specific response, and possibly in immunopathological states.

    Original languageEnglish
    Pages (from-to)71-75
    Number of pages5
    JournalEuropean Journal of Immunology
    Volume24
    Issue number1
    DOIs
    Publication statusPublished - Jan 1994

    Keywords

    • Activated human T cell
    • Antigen presentation

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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