Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study

C A Purdie, P Quinlan, L B Jordan, A Ashfield, S Ogston, J A Dewar, A M Thompson

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    83 Citations (Scopus)

    Abstract

    Background:Progesterone receptor (PR) expression assessment in early invasive breast cancer remains controversial. This study sought to re-evaluate PR expression as a potential therapeutic guide in early breast cancer; particularly in oestrogen receptor (ER)-positive, lymph node (LN)-negative disease.Methods:A population cohort of 1074 patients presenting to a single Cancer Centre over 4 years (2000-2004) underwent surgery for primary invasive breast cancer with curative intent. Prospective data collection included patient demographics, pathology, ER and PR expression, HER2 status, adjuvant chemotherapy and endocrine therapy. Progesterone receptor expression was compared with (all causes) overall survival (OS), breast cancer-specific survival (BCSS) and disease-free survival (DFS).Results:Overall survival was 71.0% and BCSS was 83.0% at median follow-up of 8.34 years. Absent PR expression was significantly associated with poorer prognosis for OS, BCSS and DFS (P
    Original languageEnglish
    JournalBritish Journal of Cancer
    Early online date3 Dec 2013
    DOIs
    Publication statusPublished - 2013

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