Prognostic and therapeutic implications of APC mutations in colorectal cancer

A. J. Quyn, R. J. C. Steele, F. A. Carey, I. S. Nathke

    Research output: Contribution to journalReview article

    7 Citations (Scopus)

    Abstract

    The adenomatous polyposis coli gene (Apc) is mutated in most colorectal cancers. The multifunctional character of the Apc protein in the regulation of beta-catenin-mediated gene transcription and cytoskeletal proteins has been well described. An important question is how this protein affects the behaviour of cells within a tumour and how its mutational status influences the prognosis for these tumours. Here we provide an overview of the functions of Apc and examine how this information can be used in the prognosis and development of directed therapy in colorectal cancer.

    Original languageEnglish
    Pages (from-to)350-356
    Number of pages7
    JournalSurgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
    Volume6
    Issue number6
    Publication statusPublished - Dec 2008

    Keywords

    • Colorectal cancer
    • Adenomatous polyposis coli
    • Familial adenomatous polyposis
    • Nonsteroidal antiinflammatory drugs
    • WNT signalling pathway
    • Replication selective adenovirus
    • Alternatively spliced region
    • Phase-II trial
    • Beta catenin
    • Colon cancer
    • Mediated apoptosis
    • Deleted adenovirus

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