Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons from Dictyostelium

Till Bretschneider, Hans G. Othmer, Cornelis J. Weijer

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Movement of cells and tissues is a basic biological process that is used in development, wound repair, the immune response to bacterial invasion, tumour formation and metastasis, and the search for food and mates. While some cell movement is random, directed movement stimulated by extracellular signals is our focus here. This involves a sequence of steps in which cells first detect extracellular chemical and/or mechanical signals via membrane receptors that activate signal transduction cascades and produce intracellular signals. These intracellular signals control the motile machinery of the cell and thereby determine the spatial localization of the sites of force generation needed to produce directed motion. Understanding how force generation within cells and mechanical interactions with their surroundings, including other cells, are controlled in space and time to produce cell-level movement is a major challenge, and involves many issues that are amenable to mathematical modelling.

Original languageEnglish
Number of pages16
JournalInterface Focus
Volume6
Issue number5
Early online date19 Aug 2016
DOIs
Publication statusPublished - 6 Oct 2016

Fingerprint

Signal transduction
Dictyostelium
Machinery
Cell Movement
Actins
Tumors
Signal Transduction
Repair
Cells
Tissue
Membranes
Biological Phenomena
Cell Communication
Neoplasm Metastasis
Food
Wounds and Injuries
Neoplasms

Keywords

  • Actin dynamics
  • Movement
  • Multicellular morphogenesis
  • Signal transduction

Cite this

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Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level : lessons from Dictyostelium. / Bretschneider, Till; Othmer, Hans G.; Weijer, Cornelis J.

In: Interface Focus, Vol. 6, No. 5, 06.10.2016.

Research output: Contribution to journalReview article

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