Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries

Zobair M. Younossi; James M. Paik; Jeffrey V. Lazarus; Patrizia Burra; Yuichiro Eguchi; Frank Tacke; Javier Crespo; Cristiane A. Villela-Nogueira; Paul N. Brennan; Hussain Abdulrahman Al-Omar; Manuel Romero-Gomez; Cyrielle Caussy; Mário Guimarães Pessoa; Kenneth Cusi; Michael Roden; Hirokazu Takahashi; Amalia Gastaldelli; Jörn M. Schattenberg; Claudia Pinto Oliveira; Takumi Kawaguchi; Yuko Eguchi; Jerome Boursier; Faisal Abaalkhail; Jeremy W. Tomlinson; Alina M. Allen; Vincent Wai-Sun Wong; Elisabetta Bugianesi; Philip N. Newsome; Jose Luis Calleja; Nicolai Brachowicz; Leire Agirre-Garrido; Douglas Maya-Miles; Habeeb I.A. Razack; Henry E. Mark; Ariana Nader; Sara Battistella; Jennifer Margier; Alessandra Risso; Maria Stepanova; Fatema Nader; Linda Henry; Laurent Castera; Saleh A. Alqahtani

doi:10.1016/j.cgh.2025.09.002

Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries

Zobair M. Younossi (Lead / Corresponding author)
, James M. Paik
, Jeffrey V. Lazarus
, Patrizia Burra
, Yuichiro Eguchi
, Frank Tacke
, Javier Crespo
, Cristiane A. Villela-Nogueira
, Paul N. Brennan
, Hussain Abdulrahman Al-Omar
, Manuel Romero-Gomez
, Cyrielle Caussy
, Mário Guimarães Pessoa
, Kenneth Cusi
, Michael Roden
, Hirokazu Takahashi
, Amalia Gastaldelli
, Jörn M. Schattenberg
, Claudia Pinto Oliveira
, Takumi Kawaguchi

Yuko Eguchi, Jerome Boursier, Faisal Abaalkhail, Jeremy W. Tomlinson, Alina M. Allen, Vincent Wai-Sun Wong, Elisabetta Bugianesi, Philip N. Newsome, Jose Luis Calleja, Nicolai Brachowicz, Leire Agirre-Garrido, Douglas Maya-Miles, Habeeb I.A. Razack, Henry E. Mark, Ariana Nader, Sara Battistella, Jennifer Margier, Alessandra Risso, Maria Stepanova, Fatema Nader, Linda Henry, Laurent Castera, Saleh A. Alqahtani

Respiratory Medicine and Gastroenterology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Original language	English
Journal	Clinical Gastroenterology and Hepatology
Early online date	8 Sept 2025
DOIs	https://doi.org/10.1016/j.cgh.2025.09.002
Publication status	E-pub ahead of print - 8 Sept 2025

Keywords

GBD
GNC
GNR
GODT
HRQL
MASH
MASLD

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.1016/j.cgh.2025.09.002

Cite this

Younossi, Z. M., Paik, J. M., Lazarus, J. V., Burra, P., Eguchi, Y., Tacke, F., Crespo, J., Villela-Nogueira, C. A., Brennan, P. N., Al-Omar, H. A., Romero-Gomez, M., Caussy, C., Pessoa, M. G., Cusi, K., Roden, M., Takahashi, H., Gastaldelli, A., Schattenberg, J. M., Oliveira, C. P., ... Alqahtani, S. A. (2025). Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries. Clinical Gastroenterology and Hepatology. Advance online publication. https://doi.org/10.1016/j.cgh.2025.09.002

@article{65023c3fe00d4818a2b80a2fcfe3e5a0,

title = "Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries",

keywords = "GBD, GNC, GNR, GODT, HRQL, MASH, MASLD",

author = "Younossi, \{Zobair M.\} and Paik, \{James M.\} and Lazarus, \{Jeffrey V.\} and Patrizia Burra and Yuichiro Eguchi and Frank Tacke and Javier Crespo and Villela-Nogueira, \{Cristiane A.\} and Brennan, \{Paul N.\} and Al-Omar, \{Hussain Abdulrahman\} and Manuel Romero-Gomez and Cyrielle Caussy and Pessoa, \{M{\'a}rio Guimar{\~a}es\} and Kenneth Cusi and Michael Roden and Hirokazu Takahashi and Amalia Gastaldelli and Schattenberg, \{J{\"o}rn M.\} and Oliveira, \{Claudia Pinto\} and Takumi Kawaguchi and Yuko Eguchi and Jerome Boursier and Faisal Abaalkhail and Tomlinson, \{Jeremy W.\} and Allen, \{Alina M.\} and \{Wai-Sun Wong\}, Vincent and Elisabetta Bugianesi and Newsome, \{Philip N.\} and Calleja, \{Jose Luis\} and Nicolai Brachowicz and Leire Agirre-Garrido and Douglas Maya-Miles and Razack, \{Habeeb I.A.\} and Mark, \{Henry E.\} and Ariana Nader and Sara Battistella and Jennifer Margier and Alessandra Risso and Maria Stepanova and Fatema Nader and Linda Henry and Laurent Castera and Alqahtani, \{Saleh A.\}",

year = "2025",

month = sep,

day = "8",

doi = "10.1016/j.cgh.2025.09.002",

language = "English",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B. Saunders",

}

Younossi, ZM, Paik, JM, Lazarus, JV, Burra, P, Eguchi, Y, Tacke, F, Crespo, J, Villela-Nogueira, CA, Brennan, PN, Al-Omar, HA, Romero-Gomez, M, Caussy, C, Pessoa, MG, Cusi, K, Roden, M, Takahashi, H, Gastaldelli, A, Schattenberg, JM, Oliveira, CP, Kawaguchi, T, Eguchi, Y, Boursier, J, Abaalkhail, F, Tomlinson, JW, Allen, AM, Wai-Sun Wong, V, Bugianesi, E, Newsome, PN, Calleja, JL, Brachowicz, N, Agirre-Garrido, L, Maya-Miles, D, Razack, HIA, Mark, HE, Nader, A, Battistella, S, Margier, J, Risso, A, Stepanova, M, Nader, F, Henry, L, Castera, L & Alqahtani, SA 2025, 'Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries', Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2025.09.002

Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries. / Younossi, Zobair M. (Lead / Corresponding author); Paik, James M.; Lazarus, Jeffrey V. et al.
In: Clinical Gastroenterology and Hepatology, 08.09.2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

T2 - The Cost of Inaction Based on Data From Nine Countries

AU - Younossi, Zobair M.

AU - Paik, James M.

AU - Lazarus, Jeffrey V.

AU - Burra, Patrizia

AU - Eguchi, Yuichiro

AU - Tacke, Frank

AU - Crespo, Javier

AU - Villela-Nogueira, Cristiane A.

AU - Brennan, Paul N.

AU - Al-Omar, Hussain Abdulrahman

AU - Romero-Gomez, Manuel

AU - Caussy, Cyrielle

AU - Pessoa, Mário Guimarães

AU - Cusi, Kenneth

AU - Roden, Michael

AU - Takahashi, Hirokazu

AU - Gastaldelli, Amalia

AU - Schattenberg, Jörn M.

AU - Oliveira, Claudia Pinto

AU - Kawaguchi, Takumi

AU - Eguchi, Yuko

AU - Boursier, Jerome

AU - Abaalkhail, Faisal

AU - Tomlinson, Jeremy W.

AU - Allen, Alina M.

AU - Wai-Sun Wong, Vincent

AU - Bugianesi, Elisabetta

AU - Newsome, Philip N.

AU - Calleja, Jose Luis

AU - Brachowicz, Nicolai

AU - Agirre-Garrido, Leire

AU - Maya-Miles, Douglas

AU - Razack, Habeeb I.A.

AU - Mark, Henry E.

AU - Nader, Ariana

AU - Battistella, Sara

AU - Margier, Jennifer

AU - Risso, Alessandra

AU - Stepanova, Maria

AU - Nader, Fatema

AU - Henry, Linda

AU - Castera, Laurent

AU - Alqahtani, Saleh A.

PY - 2025/9/8

Y1 - 2025/9/8

KW - GBD

KW - GNC

KW - GNR

KW - GODT

KW - HRQL

KW - MASH

KW - MASLD

UR - https://www.scopus.com/pages/publications/105018925207

U2 - 10.1016/j.cgh.2025.09.002

DO - 10.1016/j.cgh.2025.09.002

M3 - Article

C2 - 40930305

AN - SCOPUS:105018925207

SN - 1542-3565

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

ER -

Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data From Nine Countries

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this