Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery

Samira Bell, Andrea Patton, Jacqueline Sneddon, Peter Donnan, Thenmalar Vadiveloo, Charis Marwick, Marion Bennie, Peter Davey

    Research output: Contribution to journalMeeting abstractpeer-review


    Introduction and Aims: Rising rates of Clostridium difficile infection (CDI), including fatal cases, prompted a number of measures to be implemented in 2008 in Scottish hospitals aimed at reducing CDI. These measures included restricting the use of broad spectrum antibiotics. Within the Tayside region of Scotland, the antibiotic policy was changed from cefuroxime to flucloxacillin and gentamicin as prophylaxis in patients undergoing orthopaedic surgery. A recent small observational study carried out in Dumfries and Galloway has raised concerns that this change has led to increased rates of AKI. The aim of this study was to examine the rates of AKI before and after the antibiotic policy change in patients undergoing orthopaedic surgery.

    Original languageEnglish
    Article numberMP146
    Pages (from-to)i343-i343
    Number of pages1
    JournalNephrology Dialysis Transplantation
    Issue numbersupp. 1
    Publication statusPublished - May 2013
    Event50th European Renal Association - European Dialysis and Transplant Association Congress - Istanbul, Turkey
    Duration: 18 May 201321 May 2013

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