Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery

Samira Bell; Andrea Patton; Jacqueline Sneddon; Peter Donnan; Thenmalar Vadiveloo; Charis Marwick; Marion Bennie; Peter Davey

doi:10.1093/ndt/gft129

Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery

Samira Bell, Andrea Patton, Jacqueline Sneddon, Peter Donnan, Thenmalar Vadiveloo, Charis Marwick, Marion Bennie, Peter Davey

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Introduction and Aims: Rising rates of Clostridium difficile infection (CDI), including fatal cases, prompted a number of measures to be implemented in 2008 in Scottish hospitals aimed at reducing CDI. These measures included restricting the use of broad spectrum antibiotics. Within the Tayside region of Scotland, the antibiotic policy was changed from cefuroxime to flucloxacillin and gentamicin as prophylaxis in patients undergoing orthopaedic surgery. A recent small observational study carried out in Dumfries and Galloway has raised concerns that this change has led to increased rates of AKI. The aim of this study was to examine the rates of AKI before and after the antibiotic policy change in patients undergoing orthopaedic surgery.

Original language	English
Article number	MP146
Pages (from-to)	i343-i343
Number of pages	1
Journal	Nephrology Dialysis Transplantation
Volume	28
Issue number	supp. 1
DOIs	https://doi.org/10.1093/ndt/gft129
Publication status	Published - May 2013
Event	50th European Renal Association - European Dialysis and Transplant Association Congress - Istanbul, Turkey Duration: 18 May 2013 → 21 May 2013

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title = "Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery",

abstract = "Introduction and Aims: Rising rates of Clostridium difficile infection (CDI), including fatal cases, prompted a number of measures to be implemented in 2008 in Scottish hospitals aimed at reducing CDI. These measures included restricting the use of broad spectrum antibiotics. Within the Tayside region of Scotland, the antibiotic policy was changed from cefuroxime to flucloxacillin and gentamicin as prophylaxis in patients undergoing orthopaedic surgery. A recent small observational study carried out in Dumfries and Galloway has raised concerns that this change has led to increased rates of AKI. The aim of this study was to examine the rates of AKI before and after the antibiotic policy change in patients undergoing orthopaedic surgery.",

author = "Samira Bell and Andrea Patton and Jacqueline Sneddon and Peter Donnan and Thenmalar Vadiveloo and Charis Marwick and Marion Bennie and Peter Davey",

year = "2013",

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doi = "10.1093/ndt/gft129",

language = "English",

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journal = "Nephrology Dialysis Transplantation",

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note = "50th European Renal Association - European Dialysis and Transplant Association Congress ; Conference date: 18-05-2013 Through 21-05-2013",

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T1 - Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery

AU - Bell, Samira

AU - Patton, Andrea

AU - Sneddon, Jacqueline

AU - Donnan, Peter

AU - Vadiveloo, Thenmalar

AU - Marwick, Charis

AU - Bennie, Marion

AU - Davey, Peter

PY - 2013/5

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N2 - Introduction and Aims: Rising rates of Clostridium difficile infection (CDI), including fatal cases, prompted a number of measures to be implemented in 2008 in Scottish hospitals aimed at reducing CDI. These measures included restricting the use of broad spectrum antibiotics. Within the Tayside region of Scotland, the antibiotic policy was changed from cefuroxime to flucloxacillin and gentamicin as prophylaxis in patients undergoing orthopaedic surgery. A recent small observational study carried out in Dumfries and Galloway has raised concerns that this change has led to increased rates of AKI. The aim of this study was to examine the rates of AKI before and after the antibiotic policy change in patients undergoing orthopaedic surgery.

AB - Introduction and Aims: Rising rates of Clostridium difficile infection (CDI), including fatal cases, prompted a number of measures to be implemented in 2008 in Scottish hospitals aimed at reducing CDI. These measures included restricting the use of broad spectrum antibiotics. Within the Tayside region of Scotland, the antibiotic policy was changed from cefuroxime to flucloxacillin and gentamicin as prophylaxis in patients undergoing orthopaedic surgery. A recent small observational study carried out in Dumfries and Galloway has raised concerns that this change has led to increased rates of AKI. The aim of this study was to examine the rates of AKI before and after the antibiotic policy change in patients undergoing orthopaedic surgery.

U2 - 10.1093/ndt/gft129

DO - 10.1093/ndt/gft129

M3 - Meeting abstract

SN - 0931-0509

VL - 28

SP - i343-i343

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

IS - supp. 1

M1 - MP146

T2 - 50th European Renal Association - European Dialysis and Transplant Association Congress

Y2 - 18 May 2013 through 21 May 2013

ER -

Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery

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