Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli

Michael J. Ormsby; Síle A. Johnson; Nuria Carpena; Lynsey M. Meikle; Robert J. Goldstone; Anne McIntosh; Hannah M. Wessel; Heather E. Hulme; Ceilidh C. McConnachie; James P. R. Connolly; Andrew J. Roe; Conor Hasson; Joseph Boyd; Eamonn Fitzgerald; Konstantinos Gerasimidis; Douglas Morrison; Georgina L. Hold; Richard Hansen; Daniel Walker; David G. E. Smith; Daniel M. Wall

doi:10.1016/j.celrep.2020.01.078

Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli

Michael J. Ormsby, Síle A. Johnson, Nuria Carpena, Lynsey M. Meikle, Robert J. Goldstone, Anne McIntosh, Hannah M. Wessel, Heather E. Hulme, Ceilidh C. McConnachie, James P. R. Connolly, Andrew J. Roe, Conor Hasson, Joseph Boyd, Eamonn Fitzgerald, Konstantinos Gerasimidis, Douglas Morrison, Georgina L. Hold, Richard Hansen, Daniel Walker, David G. E. SmithDaniel M. Wall (Lead / Corresponding author)

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Abstract

The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).

Original language	English
Pages (from-to)	2297-2305.e5
Number of pages	15
Journal	Cell Reports
Volume	30
Issue number	7
Early online date	18 Feb 2020
DOIs	https://doi.org/10.1016/j.celrep.2020.01.078
Publication status	Published - 18 Feb 2020

Keywords

adherent-invasive E. coli
Crohn's disease
propionic acid
short chain fatty acid

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.01.078Licence: CC BY

Final Published VersionFinal published version, 2.21 MBLicence: CC BY

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Ormsby, M. J., Johnson, S. A., Carpena, N., Meikle, L. M., Goldstone, R. J., McIntosh, A., Wessel, H. M., Hulme, H. E., McConnachie, C. C., Connolly, J. P. R., Roe, A. J., Hasson, C., Boyd, J., Fitzgerald, E., Gerasimidis, K., Morrison, D., Hold, G. L., Hansen, R., Walker, D., ... Wall, D. M. (2020). Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. https://doi.org/10.1016/j.celrep.2020.01.078

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title = "Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli",

abstract = "The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).",

keywords = "adherent-invasive E. coli, Crohn's disease, propionic acid, short chain fatty acid",

author = "Ormsby, {Michael J.} and Johnson, {S{\'i}le A.} and Nuria Carpena and Meikle, {Lynsey M.} and Goldstone, {Robert J.} and Anne McIntosh and Wessel, {Hannah M.} and Hulme, {Heather E.} and McConnachie, {Ceilidh C.} and Connolly, {James P. R.} and Roe, {Andrew J.} and Conor Hasson and Joseph Boyd and Eamonn Fitzgerald and Konstantinos Gerasimidis and Douglas Morrison and Hold, {Georgina L.} and Richard Hansen and Daniel Walker and Smith, {David G. E.} and Wall, {Daniel M.}",

note = "Funding Information: The authors would like to thank Professor Jos{\'e} R. Penades and Dr. Nicky O{\textquoteright}Boyle for their constructive criticism and helpful experimental advice. This work was funded by Biotechnology and Biological Sciences Research Council grants BB/K008005/1 and BB/P003281/1 to D.M.W.; by a Tenovus Scotland grant to M.J.O.; by the Wellcome Trust through a Wellcome Trust PhD studentship to S.A.J. (102460/Z/13/Z) ; and by Glasgow Children's Hospital Charity, Nestle Health Services, EPSRC and Catherine McEwan Foundation grants awarded to K.G. The IBD team at the Royal Hospital for Children, Glasgow are supported by the Catherine McEwan Foundation and Yorkhill IBD fund . R.H. is supported by NHS Research Scotland Senior fellowship awards. Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = feb,

day = "18",

doi = "10.1016/j.celrep.2020.01.078",

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Ormsby, MJ, Johnson, SA, Carpena, N, Meikle, LM, Goldstone, RJ, McIntosh, A, Wessel, HM, Hulme, HE, McConnachie, CC, Connolly, JPR, Roe, AJ, Hasson, C, Boyd, J, Fitzgerald, E, Gerasimidis, K, Morrison, D, Hold, GL, Hansen, R, Walker, D, Smith, DGE & Wall, DM 2020, 'Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli', Cell Reports, vol. 30, no. 7, pp. 2297-2305.e5. https://doi.org/10.1016/j.celrep.2020.01.078

TY - JOUR

T1 - Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli

AU - Ormsby, Michael J.

AU - Johnson, Síle A.

AU - Carpena, Nuria

AU - Meikle, Lynsey M.

AU - Goldstone, Robert J.

AU - McIntosh, Anne

AU - Wessel, Hannah M.

AU - Hulme, Heather E.

AU - McConnachie, Ceilidh C.

AU - Connolly, James P. R.

AU - Roe, Andrew J.

AU - Hasson, Conor

AU - Boyd, Joseph

AU - Fitzgerald, Eamonn

AU - Gerasimidis, Konstantinos

AU - Morrison, Douglas

AU - Hold, Georgina L.

AU - Hansen, Richard

AU - Walker, Daniel

AU - Smith, David G. E.

AU - Wall, Daniel M.

N1 - Funding Information: The authors would like to thank Professor José R. Penades and Dr. Nicky O’Boyle for their constructive criticism and helpful experimental advice. This work was funded by Biotechnology and Biological Sciences Research Council grants BB/K008005/1 and BB/P003281/1 to D.M.W.; by a Tenovus Scotland grant to M.J.O.; by the Wellcome Trust through a Wellcome Trust PhD studentship to S.A.J. (102460/Z/13/Z) ; and by Glasgow Children's Hospital Charity, Nestle Health Services, EPSRC and Catherine McEwan Foundation grants awarded to K.G. The IBD team at the Royal Hospital for Children, Glasgow are supported by the Catherine McEwan Foundation and Yorkhill IBD fund . R.H. is supported by NHS Research Scotland Senior fellowship awards. Publisher Copyright: © 2020 The Author(s)

PY - 2020/2/18

Y1 - 2020/2/18

N2 - The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).

AB - The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).

KW - adherent-invasive E. coli

KW - Crohn's disease

KW - propionic acid

KW - short chain fatty acid

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U2 - 10.1016/j.celrep.2020.01.078

DO - 10.1016/j.celrep.2020.01.078

M3 - Article

C2 - 32075765

SN - 2211-1247

VL - 30

SP - 2297-2305.e5

JO - Cell Reports

JF - Cell Reports

IS - 7

ER -

Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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