@article{3cf2a648e9674719bd02de792ea0b2a5,
title = "Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive Escherichia coli",
abstract = "The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).",
keywords = "adherent-invasive E. coli, Crohn's disease, propionic acid, short chain fatty acid",
author = "Ormsby, {Michael J.} and Johnson, {S{\'i}le A.} and Nuria Carpena and Meikle, {Lynsey M.} and Goldstone, {Robert J.} and Anne McIntosh and Wessel, {Hannah M.} and Hulme, {Heather E.} and McConnachie, {Ceilidh C.} and Connolly, {James P. R.} and Roe, {Andrew J.} and Conor Hasson and Joseph Boyd and Eamonn Fitzgerald and Konstantinos Gerasimidis and Douglas Morrison and Hold, {Georgina L.} and Richard Hansen and Daniel Walker and Smith, {David G. E.} and Wall, {Daniel M.}",
note = "Funding Information: The authors would like to thank Professor Jos{\'e} R. Penades and Dr. Nicky O{\textquoteright}Boyle for their constructive criticism and helpful experimental advice. This work was funded by Biotechnology and Biological Sciences Research Council grants BB/K008005/1 and BB/P003281/1 to D.M.W.; by a Tenovus Scotland grant to M.J.O.; by the Wellcome Trust through a Wellcome Trust PhD studentship to S.A.J. (102460/Z/13/Z) ; and by Glasgow Children's Hospital Charity, Nestle Health Services, EPSRC and Catherine McEwan Foundation grants awarded to K.G. The IBD team at the Royal Hospital for Children, Glasgow are supported by the Catherine McEwan Foundation and Yorkhill IBD fund . R.H. is supported by NHS Research Scotland Senior fellowship awards. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = feb,
day = "18",
doi = "10.1016/j.celrep.2020.01.078",
language = "English",
volume = "30",
pages = "2297--2305.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Elsevier",
number = "7",
}
