Propofol 2% in critically ill patients

effect on lipids

Graeme McLeod, John Dick, Charles Wallis, Anna Patterson, Christina Cox, John Colvin

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Objective: To investigate the concentrations of triglyceride, cholesterol, and high-density lipoprotein during a 50-hr infusion of 2% propofol, starting within 24 hrs of admission to the intensive care unit (ICU). Design: Prospective, clinical study. Setting: ICU, university hospital Patients: Thirty adult patients, who were ventilated and expected to be sedated for >2 days, were studied for 50 hrs, beginning at 1800 hrs on the first day of ICU admission. Measurements and Main Results: Triglyceride, cholesterol, and high-density lipoprotein were measured at 2000, 0400, and 0800 hrs. Tumor necrosis factor (TNF)-a, interleukin (IL)-6, and C-reactive protein were measured st 2000 hrs. Median cholesterol and high-density lipoprotein concentrations were at the low end of the normal range. In seven patients, peak triglyceride concentrations were >3 mmol/L up to a maximum of 4.83 mmol/L. Although there was no statistical difference in lipid concentrations between days 1 and 2, there was an apparent pattern of increasing triglyceride concentrations. There was a correlation between peak triglyceride concentration and total propofol consumption, but there was no correlation between lipids and age, gender, or Acute Physiology and Chronic Health Evaluation II scores. There was a direct correlation between triglyceride and C-reactive protein concentrations, and an inverse correlation between cholesterol and C-reactive protein. Twenty-two patients had evidence of TNF and 11 patients had an IL-6 of >1000 pg/mL, but there was no relationship between concentrations of cytokines and triglycerides in plasma. Conclusions: Infusion of 2% propofol to critically ill patients over a 50-hr period does not result in a significant increase in triglyceride concentrations. Mean cholesterol and high-density lipoprotein concentrations were low throughout the study period. There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response.
    Original languageEnglish
    Pages (from-to)1976-1981
    Number of pages6
    JournalCritical Care Medicine
    Volume25
    Issue number12
    DOIs
    Publication statusPublished - Dec 1997

    Fingerprint

    Propofol
    Critical Illness
    Triglycerides
    Lipids
    C-Reactive Protein
    HDL Cholesterol
    Intensive Care Units
    Interleukin-6
    Tumor Necrosis Factor-alpha
    Cholesterol
    Acute-Phase Reaction
    APACHE
    Reference Values
    Prospective Studies
    Cytokines

    Cite this

    McLeod, G., Dick, J., Wallis, C., Patterson, A., Cox, C., & Colvin, J. (1997). Propofol 2% in critically ill patients: effect on lipids. Critical Care Medicine, 25(12), 1976-1981. https://doi.org/10.1097/00003246-199712000-00012
    McLeod, Graeme ; Dick, John ; Wallis, Charles ; Patterson, Anna ; Cox, Christina ; Colvin, John. / Propofol 2% in critically ill patients : effect on lipids. In: Critical Care Medicine. 1997 ; Vol. 25, No. 12. pp. 1976-1981.
    @article{8ffd9e11561f4a029b03efd460a9ac38,
    title = "Propofol 2{\%} in critically ill patients: effect on lipids",
    abstract = "Objective: To investigate the concentrations of triglyceride, cholesterol, and high-density lipoprotein during a 50-hr infusion of 2{\%} propofol, starting within 24 hrs of admission to the intensive care unit (ICU). Design: Prospective, clinical study. Setting: ICU, university hospital Patients: Thirty adult patients, who were ventilated and expected to be sedated for >2 days, were studied for 50 hrs, beginning at 1800 hrs on the first day of ICU admission. Measurements and Main Results: Triglyceride, cholesterol, and high-density lipoprotein were measured at 2000, 0400, and 0800 hrs. Tumor necrosis factor (TNF)-a, interleukin (IL)-6, and C-reactive protein were measured st 2000 hrs. Median cholesterol and high-density lipoprotein concentrations were at the low end of the normal range. In seven patients, peak triglyceride concentrations were >3 mmol/L up to a maximum of 4.83 mmol/L. Although there was no statistical difference in lipid concentrations between days 1 and 2, there was an apparent pattern of increasing triglyceride concentrations. There was a correlation between peak triglyceride concentration and total propofol consumption, but there was no correlation between lipids and age, gender, or Acute Physiology and Chronic Health Evaluation II scores. There was a direct correlation between triglyceride and C-reactive protein concentrations, and an inverse correlation between cholesterol and C-reactive protein. Twenty-two patients had evidence of TNF and 11 patients had an IL-6 of >1000 pg/mL, but there was no relationship between concentrations of cytokines and triglycerides in plasma. Conclusions: Infusion of 2{\%} propofol to critically ill patients over a 50-hr period does not result in a significant increase in triglyceride concentrations. Mean cholesterol and high-density lipoprotein concentrations were low throughout the study period. There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response.",
    author = "Graeme McLeod and John Dick and Charles Wallis and Anna Patterson and Christina Cox and John Colvin",
    year = "1997",
    month = "12",
    doi = "10.1097/00003246-199712000-00012",
    language = "English",
    volume = "25",
    pages = "1976--1981",
    journal = "Critical Care Medicine",
    issn = "0090-3493",
    publisher = "Lippincott, Williams & Wilkins",
    number = "12",

    }

    McLeod, G, Dick, J, Wallis, C, Patterson, A, Cox, C & Colvin, J 1997, 'Propofol 2% in critically ill patients: effect on lipids', Critical Care Medicine, vol. 25, no. 12, pp. 1976-1981. https://doi.org/10.1097/00003246-199712000-00012

    Propofol 2% in critically ill patients : effect on lipids. / McLeod, Graeme; Dick, John; Wallis, Charles; Patterson, Anna; Cox, Christina; Colvin, John.

    In: Critical Care Medicine, Vol. 25, No. 12, 12.1997, p. 1976-1981.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Propofol 2% in critically ill patients

    T2 - effect on lipids

    AU - McLeod, Graeme

    AU - Dick, John

    AU - Wallis, Charles

    AU - Patterson, Anna

    AU - Cox, Christina

    AU - Colvin, John

    PY - 1997/12

    Y1 - 1997/12

    N2 - Objective: To investigate the concentrations of triglyceride, cholesterol, and high-density lipoprotein during a 50-hr infusion of 2% propofol, starting within 24 hrs of admission to the intensive care unit (ICU). Design: Prospective, clinical study. Setting: ICU, university hospital Patients: Thirty adult patients, who were ventilated and expected to be sedated for >2 days, were studied for 50 hrs, beginning at 1800 hrs on the first day of ICU admission. Measurements and Main Results: Triglyceride, cholesterol, and high-density lipoprotein were measured at 2000, 0400, and 0800 hrs. Tumor necrosis factor (TNF)-a, interleukin (IL)-6, and C-reactive protein were measured st 2000 hrs. Median cholesterol and high-density lipoprotein concentrations were at the low end of the normal range. In seven patients, peak triglyceride concentrations were >3 mmol/L up to a maximum of 4.83 mmol/L. Although there was no statistical difference in lipid concentrations between days 1 and 2, there was an apparent pattern of increasing triglyceride concentrations. There was a correlation between peak triglyceride concentration and total propofol consumption, but there was no correlation between lipids and age, gender, or Acute Physiology and Chronic Health Evaluation II scores. There was a direct correlation between triglyceride and C-reactive protein concentrations, and an inverse correlation between cholesterol and C-reactive protein. Twenty-two patients had evidence of TNF and 11 patients had an IL-6 of >1000 pg/mL, but there was no relationship between concentrations of cytokines and triglycerides in plasma. Conclusions: Infusion of 2% propofol to critically ill patients over a 50-hr period does not result in a significant increase in triglyceride concentrations. Mean cholesterol and high-density lipoprotein concentrations were low throughout the study period. There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response.

    AB - Objective: To investigate the concentrations of triglyceride, cholesterol, and high-density lipoprotein during a 50-hr infusion of 2% propofol, starting within 24 hrs of admission to the intensive care unit (ICU). Design: Prospective, clinical study. Setting: ICU, university hospital Patients: Thirty adult patients, who were ventilated and expected to be sedated for >2 days, were studied for 50 hrs, beginning at 1800 hrs on the first day of ICU admission. Measurements and Main Results: Triglyceride, cholesterol, and high-density lipoprotein were measured at 2000, 0400, and 0800 hrs. Tumor necrosis factor (TNF)-a, interleukin (IL)-6, and C-reactive protein were measured st 2000 hrs. Median cholesterol and high-density lipoprotein concentrations were at the low end of the normal range. In seven patients, peak triglyceride concentrations were >3 mmol/L up to a maximum of 4.83 mmol/L. Although there was no statistical difference in lipid concentrations between days 1 and 2, there was an apparent pattern of increasing triglyceride concentrations. There was a correlation between peak triglyceride concentration and total propofol consumption, but there was no correlation between lipids and age, gender, or Acute Physiology and Chronic Health Evaluation II scores. There was a direct correlation between triglyceride and C-reactive protein concentrations, and an inverse correlation between cholesterol and C-reactive protein. Twenty-two patients had evidence of TNF and 11 patients had an IL-6 of >1000 pg/mL, but there was no relationship between concentrations of cytokines and triglycerides in plasma. Conclusions: Infusion of 2% propofol to critically ill patients over a 50-hr period does not result in a significant increase in triglyceride concentrations. Mean cholesterol and high-density lipoprotein concentrations were low throughout the study period. There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response.

    UR - http://www.scopus.com/inward/record.url?scp=0031437074&partnerID=8YFLogxK

    U2 - 10.1097/00003246-199712000-00012

    DO - 10.1097/00003246-199712000-00012

    M3 - Article

    VL - 25

    SP - 1976

    EP - 1981

    JO - Critical Care Medicine

    JF - Critical Care Medicine

    SN - 0090-3493

    IS - 12

    ER -