Prospective analysis of quality of life and survival following mesorectal excision for rectal cancer

J. Camilleri-Brennan, R. J. C. Steele

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    171 Citations (Scopus)


    Background: Little is known of how the quality of life of patients with rectal cancer changes after surgery, and whether or not quality of life is associated with and predictive of survival. The aims of this study were to address these issues. Methods: The Medical Outcomes Study Short Form 36 (SF-36), and the European Organization for the Research and Treatment of Cancer QLQ-C30 and QLQ-CR38 quality of life questionnaires were administered to patients before surgery for rectal cancer, on discharge home and at 3-month intervals after operation for up to 1 year. Survival was measured in days from the time of surgery to death. Results: Sixty-five patients with a median age of 67 years participated. Most quality of life scores dropped significantly below baseline in the early postoperative period. From the third month onwards some scores, such as the global quality of life score and emotional function score on the QLQ-C30, improved. Other scores, including role function, fatigue and pain on the QLQ-C30, were similar to baseline values after 3-6 months and remained unchanged. However, scores such as sexual enjoyment and male sexual problems on the QLQ-CR38 were worse than baseline in the early postoperative period and remained poor thereafter. Stepwise regression analyses showed that preoperative quality of life dimension scores for physical function, nausea/vomiting and sexual enjoyment, together with age, predicted postoperative 1-year survival with an accuracy of 76.8 per cent. Conclusion: The findings of this study confirm that quality of life after rectal cancer surgery changes with time. It is generally worst in the early postoperative period. Preoperative quality of life is a good predictor of survival at 1 year. © 2001 British Journal of Surgery Society Ltd
    Original languageEnglish
    Pages (from-to)1617-1622
    Number of pages6
    JournalBritish Journal of Surgery
    Issue number12
    Publication statusPublished - Dec 2001


    • Adult
    • Aged
    • Aged, 80 and over
    • Colorectal Surgery
    • Female
    • Health Status
    • Humans
    • Male
    • Middle Aged
    • Postoperative Period
    • Prospective Studies
    • Quality of Life
    • Questionnaires
    • Rectal Neoplasms
    • Regression Analysis
    • Survival Analysis
    • Time Factors


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