Prospective parallel randomized trial of the MultiCyte™ ThinPrep imaging system

the Scottish experience

T. J. Palmer, S. M. Nicoll, A. J. Park, D. Bishop, M. E. McKean, L. Baker, J. E. A. Imrie

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Background: Computer-assisted screening of cervical liquid-based cytology (LBC) preparations using the ThinPrep® Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte™ has not been described in a well-established national screening programme with a low incidence of high-grade dyskaryosis. Objectives: To assess the impact of computer-assisted screening within the Scottish Cervical Screening Programme (SCSP). Methods: Two groups of three laboratories, each sharing a ThinPrep® Imager, screened 79366 slides randomized to test and 90551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false-negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms. Results: Inadequate and negative reporting rates were significantly lower and low-grade reporting rates significantly higher in the imager arm. Imager-assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2+ or CIN3+. Positive, abnormal and total predictive values (high-grade, low-grade and all abnormal cytology found to be CIN2+, respectively) were similar in both arms. Productivity was significantly higher in the imager arm. Conclusion: Computer-assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.
    Original languageEnglish
    Pages (from-to)235-245
    Number of pages11
    JournalCytopathology : Official Journal of the British Society for Clinical Cytology
    Volume24
    Issue number4
    DOIs
    Publication statusPublished - Aug 2013

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    Cell Biology
    Cervical Intraepithelial Neoplasia
    Histology
    Sensitivity and Specificity
    Incidence

    Cite this

    Palmer, T. J. ; Nicoll, S. M. ; Park, A. J. ; Bishop, D. ; McKean, M. E. ; Baker, L. ; Imrie, J. E. A. / Prospective parallel randomized trial of the MultiCyte™ ThinPrep imaging system : the Scottish experience. In: Cytopathology : Official Journal of the British Society for Clinical Cytology. 2013 ; Vol. 24, No. 4. pp. 235-245.
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    title = "Prospective parallel randomized trial of the MultiCyte™ ThinPrep imaging system: the Scottish experience",
    abstract = "Background: Computer-assisted screening of cervical liquid-based cytology (LBC) preparations using the ThinPrep{\circledR} Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte™ has not been described in a well-established national screening programme with a low incidence of high-grade dyskaryosis. Objectives: To assess the impact of computer-assisted screening within the Scottish Cervical Screening Programme (SCSP). Methods: Two groups of three laboratories, each sharing a ThinPrep{\circledR} Imager, screened 79366 slides randomized to test and 90551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false-negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms. Results: Inadequate and negative reporting rates were significantly lower and low-grade reporting rates significantly higher in the imager arm. Imager-assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2+ or CIN3+. Positive, abnormal and total predictive values (high-grade, low-grade and all abnormal cytology found to be CIN2+, respectively) were similar in both arms. Productivity was significantly higher in the imager arm. Conclusion: Computer-assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.",
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    Prospective parallel randomized trial of the MultiCyte™ ThinPrep imaging system : the Scottish experience. / Palmer, T. J.; Nicoll, S. M.; Park, A. J.; Bishop, D.; McKean, M. E.; Baker, L.; Imrie, J. E. A.

    In: Cytopathology : Official Journal of the British Society for Clinical Cytology, Vol. 24, No. 4, 08.2013, p. 235-245.

    Research output: Contribution to journalArticle

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    AU - Palmer, T. J.

    AU - Nicoll, S. M.

    AU - Park, A. J.

    AU - Bishop, D.

    AU - McKean, M. E.

    AU - Baker, L.

    AU - Imrie, J. E. A.

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    PY - 2013/8

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    N2 - Background: Computer-assisted screening of cervical liquid-based cytology (LBC) preparations using the ThinPrep® Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte™ has not been described in a well-established national screening programme with a low incidence of high-grade dyskaryosis. Objectives: To assess the impact of computer-assisted screening within the Scottish Cervical Screening Programme (SCSP). Methods: Two groups of three laboratories, each sharing a ThinPrep® Imager, screened 79366 slides randomized to test and 90551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false-negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms. Results: Inadequate and negative reporting rates were significantly lower and low-grade reporting rates significantly higher in the imager arm. Imager-assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2+ or CIN3+. Positive, abnormal and total predictive values (high-grade, low-grade and all abnormal cytology found to be CIN2+, respectively) were similar in both arms. Productivity was significantly higher in the imager arm. Conclusion: Computer-assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.

    AB - Background: Computer-assisted screening of cervical liquid-based cytology (LBC) preparations using the ThinPrep® Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte™ has not been described in a well-established national screening programme with a low incidence of high-grade dyskaryosis. Objectives: To assess the impact of computer-assisted screening within the Scottish Cervical Screening Programme (SCSP). Methods: Two groups of three laboratories, each sharing a ThinPrep® Imager, screened 79366 slides randomized to test and 90551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false-negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms. Results: Inadequate and negative reporting rates were significantly lower and low-grade reporting rates significantly higher in the imager arm. Imager-assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2+ or CIN3+. Positive, abnormal and total predictive values (high-grade, low-grade and all abnormal cytology found to be CIN2+, respectively) were similar in both arms. Productivity was significantly higher in the imager arm. Conclusion: Computer-assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.

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