Proteasome, the Recycle Bin of the Cancer Cell

Amy Dunne Miller; Vasudha Tandon; Sourav Banerjee; Nilabja Sikdar

doi:10.1201/9781003394693-7

Proteasome, the Recycle Bin of the Cancer Cell

Amy Dunne Miller
, Vasudha Tandon
, Sourav Banerjee
, Nilabja Sikdar

MED Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Downloads (Pure)

Abstract

Proteolysis is an integral cellular function which not only allows correction of protein synthesis mistakes, such as misfolded protein, but also recycles unnecessary proteins, therefore maintaining an amino acid reservoir for protein synthesis. The bulk of protein break down falls to a large multi-subunit complex, the 26S proteasome, dubbed the ‘recycling bin of the cell’. Considering the extent of proteasomal involvement in most cellular processes, it is unsurprising that the proteasome is also implicated in pathogenesis such as cancer. This chapter provides an overview of the history of the proteasome discovery, proteasome structure and regulation; as well as an initial insight into the role it plays in different cancer types.

Original language	English
Title of host publication	Handbook of Proteases in Cancer
Subtitle of host publication	Therapeutic Aspects
Editors	Sajal Chakraborti
Publisher	CRC Press
Chapter	5
Pages	53-69
Number of pages	17
ISBN (Electronic)	9781040166543
ISBN (Print)	9781032489520
DOIs	https://doi.org/10.1201/9781003394693-7
Publication status	Published - 17 Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ubiquitin proteasome system
proteasome
proteolysis
cancer

ASJC Scopus subject areas

General Social Sciences
General Medicine
General Immunology and Microbiology
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

Access to Document

10.1201/9781003394693-7

Author Accepted ManuscriptAccepted author manuscript, 783 KBLicence: CC BY-NC-ND

Cite this

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AU - Sikdar, Nilabja

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ER -

Proteasome, the Recycle Bin of the Cancer Cell

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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