Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes.

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    75 Citations (Scopus)

    Abstract

    Chemoprotection has established itself as a "major arm" in the "war against cancer" and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.

    Original languageEnglish
    Pages (from-to)595-610
    Number of pages16
    JournalMini-Reviews in Medicinal Chemistry
    Volume2
    Issue number6
    DOIs
    Publication statusPublished - 2002

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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