TY - JOUR
T1 - Protection against cancer by plant phenylpropenoids
T2 - induction of mammalian anticarcinogenic enzymes.
AU - Dinkova-Kostova, A. T.
PY - 2002
Y1 - 2002
N2 - Chemoprotection has established itself as a "major arm" in the "war against cancer" and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.
AB - Chemoprotection has established itself as a "major arm" in the "war against cancer" and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0011985195&partnerID=8YFLogxK
U2 - 10.2174/1389557023405558
DO - 10.2174/1389557023405558
M3 - Review article
C2 - 12370043
AN - SCOPUS:0011985195
SN - 1389-5575
VL - 2
SP - 595
EP - 610
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 6
ER -
