Protection against electrophile and oxidative stress by induction of phase 2 genes: The quest for the elusive sensor that responds to inducers

Keyphrases

• Inducer 100%
• Oxidative Stress 100%
• Electrophilic Stress 100%
• Kelch-like ECH-associated Protein 1 (Keap1) 40%
• Reactive Cysteine Residues 40%
• Cytoskeleton 20%
• Damaging Effects 20%
• Highly Effective 20%
• Effective Strategies 20%
• Group by 20%
• Dissociation 20%
• Alkylation 20%
• Glutathione 20%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 20%
• Thiols 20%
• Conformational Change 20%
• Nuclear Translocation 20%
• Nuclear Factor 20%
• Cell-based Sensor 20%
• Electrophile 20%
• Oxidation-reduction 20%
• Transcription Factor Nrf2 20%
• Thiol Groups 20%
• Kelch Domain 20%
• Chronic Degenerative Diseases 20%
• Antioxidant 20%
• Cytochrome P450 (CYP450) 20%
• Glucuronic Acid 20%
• Small Maf 20%
• Endogenous Ligand 20%
• Multi-domain 20%
• Universal Property 20%
• Cysteine-rich Protein 20%

Biochemistry, Genetics and Molecular Biology

• Oxidative Stress 100%
• Electrophilic Stress 100%
• Cysteine 100%
• Transcription Factor Nrf2 66%
• Thiol 66%
• Enzyme 33%
• Actin 33%
• Cytoskeleton 33%
• Transcription 33%
• Conformational Change 33%
• Kelch Motif 33%
• Glucuronic Acid 33%
• Oxidation Reduction Reaction 33%
• Alkylation 33%
• Glutathione 33%
• Cytochrome P450 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Cysteine 100%
• Electrophile 100%
• Oxidizing Agent 66%
• Transcription Factor Nrf2 66%
• Malignant Neoplasm 33%
• Actin 33%
• Antioxidant 33%
• Glutathione 33%
• Nuclear Factor 33%
• Thiol Group 33%
• Cytochrome P450 33%
• Glucuronic Acid 33%
• Degenerative Disease 33%
• Thiol 33%