Protective effect of salivary nitrate and microbial nitrate reductase activity against caries

J. J. Doel, M. P. Hector, C. V. Amirtham, L. A. Al-Anzan, N. Benjamin, R. P. Allaker (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    74 Citations (Scopus)

    Abstract

    To test the hypothesis that a combination of high salivary nitrate and high nitrate-reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate-reducing ability. Production of nitrite from salivary nitrate by commensal nitrate-reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.

    Original languageEnglish
    Pages (from-to)424-428
    Number of pages5
    JournalEuropean Journal of Oral Sciences
    Volume112
    Issue number5
    DOIs
    Publication statusPublished - 29 Sep 2004

    Keywords

    • Dental caries
    • Diet
    • Nitrate
    • Nitric oxide
    • Streptococcus mutans

    Fingerprint Dive into the research topics of 'Protective effect of salivary nitrate and microbial nitrate reductase activity against caries'. Together they form a unique fingerprint.

    Cite this