Protective effect of salivary nitrate and microbial nitrate reductase activity against caries

J. J. Doel; M. P. Hector; C. V. Amirtham; L. A. Al-Anzan; N. Benjamin; R. P. Allaker

doi:10.1111/j.1600-0722.2004.00153.x

Protective effect of salivary nitrate and microbial nitrate reductase activity against caries

J. J. Doel, M. P. Hector, C. V. Amirtham, L. A. Al-Anzan, N. Benjamin, R. P. Allaker (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

To test the hypothesis that a combination of high salivary nitrate and high nitrate-reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate-reducing ability. Production of nitrite from salivary nitrate by commensal nitrate-reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.

Original language	English
Pages (from-to)	424-428
Number of pages	5
Journal	European Journal of Oral Sciences
Volume	112
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0722.2004.00153.x
Publication status	Published - 29 Sept 2004

Keywords

Dental caries
Diet
Nitrate
Nitric oxide
Streptococcus mutans

ASJC Scopus subject areas

Dentistry(all)

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10.1111/j.1600-0722.2004.00153.x

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AU - Benjamin, N.

AU - Allaker, R. P.

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AB - To test the hypothesis that a combination of high salivary nitrate and high nitrate-reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate-reducing ability. Production of nitrite from salivary nitrate by commensal nitrate-reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.

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Protective effect of salivary nitrate and microbial nitrate reductase activity against caries

Abstract

Keywords

ASJC Scopus subject areas

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