Protein families secreted by nematodes to modulate host immunity

Florent Colomb; Henry McSorley

doi:10.1016/j.mib.2025.102582

Protein families secreted by nematodes to modulate host immunity

Florent Colomb
, Henry McSorley (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

119 Downloads (Pure)

Abstract

Parasitic nematodes release a wide variety of immunomodulatory proteins, which allow them to escape the host’s immune-mediated killing or ejection mechanisms. This immunomodulation is mediated by nematode excretory/secretory (E/S) products, which contain multiple families of immunomodulatory proteins. Many of these families are conserved across different parasitic nematodes, while others are apparently unique to specific species. While some E/S products interact with host proteins, others have evolved to target host lipids, glycans, and metabolites. In this review, we will focus on three families of immunomodulatory proteins, which are particularly expanded in intestinal nematodes: the venom allergen-like proteins, the apyrases, and the complement control protein domain-containing proteins. These families of proteins suppress host immune responses, and evidence is gathering that these could be effective vaccine antigens against these intractable parasites.

Original language	English
Article number	102582
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	84
Early online date	15 Feb 2025
DOIs	https://doi.org/10.1016/j.mib.2025.102582
Publication status	Published - Apr 2025

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10.1016/j.mib.2025.102582Licence: CC BY

Final Published VersionFinal published version, 1.51 MBLicence: CC BY

Molecular Regulators of the Alarmin IL-33 in Health and Disease
McSorley, H. (Investigator)
1/07/21 → 31/03/27
Project: Research

Cite this

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abstract = "Parasitic nematodes release a wide variety of immunomodulatory proteins, which allow them to escape the host{\textquoteright}s immune-mediated killing or ejection mechanisms. This immunomodulation is mediated by nematode excretory/secretory (E/S) products, which contain multiple families of immunomodulatory proteins. Many of these families are conserved across different parasitic nematodes, while others are apparently unique to specific species. While some E/S products interact with host proteins, others have evolved to target host lipids, glycans, and metabolites. In this review, we will focus on three families of immunomodulatory proteins, which are particularly expanded in intestinal nematodes: the venom allergen-like proteins, the apyrases, and the complement control protein domain-containing proteins. These families of proteins suppress host immune responses, and evidence is gathering that these could be effective vaccine antigens against these intractable parasites.",

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AB - Parasitic nematodes release a wide variety of immunomodulatory proteins, which allow them to escape the host’s immune-mediated killing or ejection mechanisms. This immunomodulation is mediated by nematode excretory/secretory (E/S) products, which contain multiple families of immunomodulatory proteins. Many of these families are conserved across different parasitic nematodes, while others are apparently unique to specific species. While some E/S products interact with host proteins, others have evolved to target host lipids, glycans, and metabolites. In this review, we will focus on three families of immunomodulatory proteins, which are particularly expanded in intestinal nematodes: the venom allergen-like proteins, the apyrases, and the complement control protein domain-containing proteins. These families of proteins suppress host immune responses, and evidence is gathering that these could be effective vaccine antigens against these intractable parasites.

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DO - 10.1016/j.mib.2025.102582

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VL - 84

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

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Protein families secreted by nematodes to modulate host immunity

Abstract

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Molecular Regulators of the Alarmin IL-33 in Health and Disease

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