Protein histidine phosphatase activity in rat liver and spinach leaves

Harry R. Matthews, Carol MacKintosh

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Whole cell extracts from rat liver or spinach leaves contain divalent ion-independent protein histidine phosphatase activity due to phosphatases of the PP1/PP2A family. In the rat liver extract, almost all the activity was found in the PP1, PP2A(1) and PP2A(2) peaks. In the spinach leaf extract, four phosphorylase phosphatase activity peaks were resolved - three containing PP1 and one containing PP2A - and all showed histidine phosphatase activity. Thus, protein histidine phosphatase activity is expressed in the cytosolic forms of protein phosphatases of the PP1/PP2A family in mammalian and plant cells.

    Original languageEnglish
    Pages (from-to)51-54
    Number of pages4
    JournalFEBS Letters
    Issue number1
    Publication statusPublished - 1995


    Dive into the research topics of 'Protein histidine phosphatase activity in rat liver and spinach leaves'. Together they form a unique fingerprint.

    Cite this