Protein kinase B (Akt) regulation and function in T lymphocytes

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    101 Citations (Scopus)

    Abstract

    Protein kinase B1 (PKB)1-5 is a serine/threonine kinase that is activated by cytokines, antigen receptors, the costimulator CD28 and chemokines in lymphocytes6-11. PKB is thus poised to contribute to a variety of immune activation responses. A number of functions have been ascribed to PKB in different cell lineages including the regulation of cell survival, cytokine gene induction and cell cycle progression. In the present article the mechanisms that control PKB activity in T lymphocytes will be reviewed and the function of this kinase in the immune system will be discussed.

    Original languageEnglish
    Pages (from-to)19-26
    Number of pages8
    JournalSeminars in Immunology
    Volume14
    Issue number1
    DOIs
    Publication statusPublished - Feb 2002

    Keywords

    • Antigen receptor
    • Chemokines
    • Interleukin-2
    • PKB
    • T lymphocytes

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