Protein kinase B (Akt) regulation and function in T lymphocytes

Doreen Cantrell

doi:10.1006/smim.2001.0338

Protein kinase B (Akt) regulation and function in T lymphocytes

Doreen Cantrell

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

Abstract

Protein kinase B₁ (PKB)^1-5 is a serine/threonine kinase that is activated by cytokines, antigen receptors, the costimulator CD28 and chemokines in lymphocytes^6-11. PKB is thus poised to contribute to a variety of immune activation responses. A number of functions have been ascribed to PKB in different cell lineages including the regulation of cell survival, cytokine gene induction and cell cycle progression. In the present article the mechanisms that control PKB activity in T lymphocytes will be reviewed and the function of this kinase in the immune system will be discussed.

Original language	English
Pages (from-to)	19-26
Number of pages	8
Journal	Seminars in Immunology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1006/smim.2001.0338
Publication status	Published - Feb 2002

Keywords

Antigen receptor
Chemokines
Interleukin-2
PKB
T lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1006/smim.2001.0338

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AB - Protein kinase B1 (PKB)1-5 is a serine/threonine kinase that is activated by cytokines, antigen receptors, the costimulator CD28 and chemokines in lymphocytes6-11. PKB is thus poised to contribute to a variety of immune activation responses. A number of functions have been ascribed to PKB in different cell lineages including the regulation of cell survival, cytokine gene induction and cell cycle progression. In the present article the mechanisms that control PKB activity in T lymphocytes will be reviewed and the function of this kinase in the immune system will be discussed.

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KW - Chemokines

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Protein kinase B (Akt) regulation and function in T lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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