Protein kinase C and beyond

Martin Spitaler, Doreen A Cantrell

    Research output: Contribution to journalReview articlepeer-review

    235 Citations (Scopus)

    Abstract

    Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells. Additionally, mammals express several other diacylglycerol binding proteins that are linked to a network of key signal transduction pathways that control lymphocyte biology. Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation.

    Original languageEnglish
    Pages (from-to)785-790
    Number of pages6
    JournalNature Immunology
    Volume5
    Issue number8
    DOIs
    Publication statusPublished - Aug 2004

    Keywords

    • PKC-THETA
    • ANTIGEN RECEPTOR
    • DIACYLGLYCEROL
    • LYMPHOCYTE ACTIVATION
    • KAPPA-B ACTIVATION
    • TYROSINE KINASES
    • ALPHA
    • IN-VIVO
    • PHORBOL ESTER
    • T-CELL-ACTIVATION

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