Protein kinase networks that limit TLR signalling

Kristopher Clark

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    TLRs (Toll-like receptors) detect invading micro-organisms which triggers the production of pro-inflammatory mediators needed to combat infection. Although these signalling networks are required to protect the host against invading pathogens, dysregulation of TLR pathways contributes to the development of chronic inflammatory diseases and autoimmune disorders. Molecular mechanisms have therefore evolved to restrict the strength of TLR signalling. In the present review, I highlight recent advances in our understanding of the protein kinase networks required to suppress the innate immune response by negatively regulating TLR signalling and/or promoting the secretion of anti-inflammatory cytokines. I present my discoveries on the key roles of the IKK (inhibitor of nuclear factor ?B kinase)-related kinases and the SIKs (salt-inducible kinases) in limiting innate immunity within the greater context of the field.
    Original languageEnglish
    Pages (from-to)11-24
    Number of pages14
    JournalBiochemical Society Transactions
    Issue number1
    Publication statusPublished - 1 Feb 2014


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