Protein kinases - The major drug targets of the twenty-first century?

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    Abstract

    Protein phosphorylation regulates most aspects of cell life, whereas abnormal phosphorylation is a cause or consequence of disease. A growing interest in developing orally active protein-kinase inhibitors has recently culminated in the approval of the first of these drugs for clinical use. Protein kinases have now become the second most important group of drug targets, after G-protein-coupled receptors. Here, I give a personal view of some of the most important advances that have shaped this field.

    Original languageEnglish
    Pages (from-to)309-315
    Number of pages7
    JournalNature Reviews Drug Discovery
    Volume1
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2002

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