Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

E.F. Da Cruz e Silva, V. Hughes, P. McDonald, M.J.R. Stark, P.T.W. Cohen

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    28 Citations (Scopus)


    cDNAs encoding three protein phosphatases, termed PP2B(w) (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.

    Original languageEnglish
    Pages (from-to)269-272
    Number of pages4
    JournalBiochimica et Biophysica Acta: General Subjects
    Issue number2
    Publication statusPublished - 13 Jun 1991

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