TY - JOUR
T1 - Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes
AU - Silva, E.F. Da Cruz e
AU - Hughes, V.
AU - McDonald, P.
AU - Stark, M.J.R.
AU - Cohen, P.T.W.
PY - 1991/6/13
Y1 - 1991/6/13
N2 - cDNAs encoding three protein phosphatases, termed PP2B(w) (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.
AB - cDNAs encoding three protein phosphatases, termed PP2B(w) (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.
U2 - 10.1016/0167-4781(91)90023-F
DO - 10.1016/0167-4781(91)90023-F
M3 - Comment/debate
SN - 0304-4165
VL - 1089
SP - 269
EP - 272
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 2
ER -